KFU. Card publication. Spectroscopic and in vitro investigations of boron(III) complex with meso-4-methoxycarbonylpropylsubstituted dipyrromethene for fluorescence bioimaging applications

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SPECTROSCOPIC AND IN VITRO INVESTIGATIONS OF BORON(III) COMPLEX WITH MESO-4-METHOXYCARBONYLPROPYLSUBSTITUTED DIPYRROMETHENE FOR FLUORESCENCE BIOIMAGING APPLICATIONS

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Islamov Daut Rinatovich, author

Kayumov Ayrat Rashitovich, author

Pavelev Roman Sergeevich, author

Usachev Konstantin Sergeevich, author

Bibliographic description in the original language

Guseva G, Antina E, Berezin M, Spectroscopic and in vitro investigations of boron(III) complex with meso-4-methoxycarbonylpropylsubstituted dipyrromethene for fluorescence bioimaging applications//Molecules. - 2020. - Vol.25, Is.19. - Art. � 4541.

Annotation

This study focuses on the behavior of a new fluorescent marker for labeling individual biomolecules and staining cell organelles developed on a meso-substituted BODIPY platform. Boron(III) complex with meso-4-methoxycarbonylpropylsubstituted 3,3',5,5'-tetramethyl-2,2'-dipyrromethene has been synthesized and identified via visible, UV-, NMR- and MS-spectra X-ray. The behavior of fluorophore in solutions has been studied with various experimental techniques. It has been found that luminophore exhibits a high quantum yield (almost ~100–75%) in the blue-green region (513–520 nm) and has high photostability. In addition, biological analysis indicates that the fluorophore exhibits a tendency to effectively penetrate into cell membranes. On the other hand, the proposed BODIPY can be used to study the significant differences among a large number of pathogens of mycotic infections, as well as to visualize structural changes in the plasma membrane, which is necessary for the clearance of mammalian cells undergoing apoptotic cell death.

Keywords

dipyrromethene, BODIPY, fluorophore, biomarker, pathogenic microorganisms

The name of the journal

Molecules

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092559267&doi=10.3390%2fmolecules25194541&partnerID=40&md5=dda95582ac829e12cde07febd7711669

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=240250&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Islamov Daut Rinatovich	ru_RU
dc.contributor.author	Kayumov Ayrat Rashitovich	ru_RU
dc.contributor.author	Pavelev Roman Sergeevich	ru_RU
dc.contributor.author	Usachev Konstantin Sergeevich	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Guseva G, Antina E, Berezin M, Spectroscopic and in vitro investigations of boron(III) complex with meso-4-methoxycarbonylpropylsubstituted dipyrromethene for fluorescence bioimaging applications//Molecules. - 2020. - Vol.25, Is.19. - Art. � 4541.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=240250&p_lang=2	ru_RU
dc.description.abstract	Molecules	ru_RU
dc.description.abstract	This study focuses on the behavior of a new fluorescent marker for labeling individual biomolecules and staining cell organelles developed on a meso-substituted BODIPY platform. Boron(III) complex with meso-4-methoxycarbonylpropylsubstituted 3,3',5,5'-tetramethyl-2,2'-dipyrromethene has been synthesized and identified via visible, UV-, NMR- and MS-spectra X-ray. The behavior of fluorophore in solutions has been studied with various experimental techniques. It has been found that luminophore exhibits a high quantum yield (almost ~100–75%) in the blue-green region (513–520 nm) and has high photostability. In addition, biological analysis indicates that the fluorophore exhibits a tendency to effectively penetrate into cell membranes. On the other hand, the proposed BODIPY can be used to study the significant differences among a large number of pathogens of mycotic infections, as well as to visualize structural changes in the plasma membrane, which is necessary for the clearance of mammalian cells undergoing apoptotic cell death.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	dipyrromethene	ru_RU
dc.subject	BODIPY	ru_RU
dc.subject	fluorophore	ru_RU
dc.subject	biomarker	ru_RU
dc.subject	pathogenic microorganisms	ru_RU
dc.title	Spectroscopic and in vitro investigations of boron(III) complex with meso-4-methoxycarbonylpropylsubstituted dipyrromethene for fluorescence bioimaging applications	ru_RU
dc.type	Articles in international journals and collections	ru_RU