KFU. Card publication. Photocontrol of Endogenous Glycine Receptors In Vivo

KAZAN
FEDERAL UNIVERSITY

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PHOTOCONTROL OF ENDOGENOUS GLYCINE RECEPTORS IN VIVO

Form of presentation

Articles in international journals and collections

Year of publication

2020

Язык

английский

Authors, employees of KFU

Mukhametova Elvira Rishatovna, author

Bibliographic description in the original language

Gomila, A. M., Rustler, K., Maleeva, G., Nin-Hill, A., Wutz, D., Bautista-Barrufet, A., ... & Ponomareva, D. (2020). Photocontrol of endogenous glycine receptors in vivo. Cell Chemical Biology.

Annotation

Cell Chemical Biology

Keywords

glycine receptors in vivo photopharmacology optopharmacology inhibitory neurotransmission CNS photoswitch

The name of the journal

Cell Chemical Biology

URL

https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30302-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451945620303020%3Fshowall%3Dtrue

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=237608&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Mukhametova Elvira Rishatovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Gomila, A. M., Rustler, K., Maleeva, G., Nin-Hill, A., Wutz, D., Bautista-Barrufet, A., ... & Ponomareva, D. (2020). Photocontrol of endogenous glycine receptors in vivo. Cell Chemical Biology.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=237608&p_lang=2	ru_RU
dc.description.abstract	Cell Chemical Biology	ru_RU
dc.description.abstract	Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Photocontrol of Endogenous Glycine Receptors In Vivo	ru_RU
dc.type	Articles in international journals and collections	ru_RU