Form of presentation | Articles in international journals and collections |
Year of publication | 2020 |
Язык | английский |
|
Mukhametova Elvira Rishatovna, author
|
Bibliographic description in the original language |
Gomila, A. M., Rustler, K., Maleeva, G., Nin-Hill, A., Wutz, D., Bautista-Barrufet, A., ... & Ponomareva, D. (2020). Photocontrol of endogenous glycine receptors in vivo. Cell Chemical Biology. |
Annotation |
Cell Chemical Biology |
Keywords |
glycine receptors
in vivo
photopharmacology
optopharmacology
inhibitory neurotransmission
CNS
photoswitch |
The name of the journal |
Cell Chemical Biology
|
URL |
https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(20)30302-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2451945620303020%3Fshowall%3Dtrue |
Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=237608&p_lang=2 |
Full metadata record ![](https://shelly.kpfu.ru/pdf/picture/arrow_black_right.gif) |
Field DC |
Value |
Language |
dc.contributor.author |
Mukhametova Elvira Rishatovna |
ru_RU |
dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
dc.date.issued |
2020 |
ru_RU |
dc.identifier.citation |
Gomila, A. M., Rustler, K., Maleeva, G., Nin-Hill, A., Wutz, D., Bautista-Barrufet, A., ... & Ponomareva, D. (2020). Photocontrol of endogenous glycine receptors in vivo. Cell Chemical Biology. |
ru_RU |
dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=237608&p_lang=2 |
ru_RU |
dc.description.abstract |
Cell Chemical Biology |
ru_RU |
dc.description.abstract |
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo, and displays an allosteric mechanism of action. The photomanipulation of glycinergic neurotransmission opens new avenues to understanding inhibitory circuits in intact animals and to developing drug-based phototherapies. |
ru_RU |
dc.language.iso |
ru |
ru_RU |
dc.subject |
|
ru_RU |
dc.title |
Photocontrol of Endogenous Glycine Receptors In Vivo |
ru_RU |
dc.type |
Articles in international journals and collections |
ru_RU |
|