KFU. Card publication. Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress

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HYDROGEN SULFIDE ALLEVIATES ANXIETY, MOTOR, AND COGNITIVE DYSFUNCTIONS IN RATS WITH MATERNAL HYPERHOMOCYSTEINEMIA VIA MITIGATION OF OXIDATIVE STRESS

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Bogatova Kseniya Sergeevna, author

Gerasimova Elena Vyacheslavovna, author

Ziyatdinova Guzel Kamilevna, author

Sitdikova Guzel Faritovna, author

Yakovlev Aleksey Valerevich, author

Yakovleva Olga Vladislavovna, author

Other authors

Hermann Anton , author

Authors, postgraduates KFU

Shakhmatova Viktoriya Igorevna, postgraduate kfu

Authors, students KFU

Bogatova Kseniya Sergeevna, author

Mukhtarova Renata Almazovna, author

Bibliographic description in the original language

Yakovleva, O. Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress / O. Yakovleva, K. Bogatova, R. Mukhtarova, A. Yakovlev, V. Shakhmatova, E. Gerasimova, G. Ziyatdinova, A. Hermann, G. Sitdikova // Biomolecules. - 2020. - V. 10. - � 7. - Article 995. - 23 p.

Annotation

Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids, including homocysteine and exerts neuroprotective effects. An increase of homocysteine during pregnancy impairs fetal growth and development of the offspring due to severe oxidative stress. We analyzed the effects of the H2S donor-sodium hydrosulfide (NaHS) administered to female rats with hyperhomocysteinemia (hHcy) on behavioral impairments and levels of oxidative stress of their offspring. Rats born from females fed with control or high methionine diet, with or without H2S donor injections were investigated. Rats with maternal hHcy exhibit increased levels of total locomotor activity and anxiety, decreased muscle endurance and motor coordination, abnormalities of fine motor control, as well as reduced spatial memory and learning. Oxidative stress in brain tissues measured by activity of glutathione peroxidases and the level of malondialdehyde was higher in rats with maternal hHcy. Concentrations of H2S and the activity and expression of the H2S generating enzyme-cystathionine-beta synthase-were lower compared to the control group. Administration of the H2S donor to females with hHcy during pregnancy prevented behavioral alterations and oxidative stress of their offspring. The acquisition of behavioral together with biochemical studies will add to our knowledge about homocysteine neurotoxicity and proposes H2S as a potential agent for therapy of hHcy associated disorders.

Keywords

hydrogen sulfide (H2S), maternal hyperhomocysteinemia (hHcy), locomotor activity, anxiety, learning and memory, motor dysfunction, H2S production, oxidative stress

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087710864&doi=10.3390%2fbiom10070995&partnerID=40&md5=a921a4fcc778dc3925eb8e3bea41ed32

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=237031&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogatova Kseniya Sergeevna	ru_RU
dc.contributor.author	Gerasimova Elena Vyacheslavovna	ru_RU
dc.contributor.author	Ziyatdinova Guzel Kamilevna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Yakovlev Aleksey Valerevich	ru_RU
dc.contributor.author	Yakovleva Olga Vladislavovna	ru_RU
dc.contributor.author	Hermann Anton	ru_RU
dc.contributor.author	Bogatova Kseniya Sergeevna	ru_RU
dc.contributor.author	Mukhtarova Renata Almazovna	ru_RU
dc.contributor.author	Shakhmatova Viktoriya Igorevna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Yakovleva, O. Hydrogen sulfide alleviates anxiety, motor, and cognitive dysfunctions in rats with maternal hyperhomocysteinemia via mitigation of oxidative stress / O. Yakovleva, K. Bogatova, R. Mukhtarova, A. Yakovlev, V. Shakhmatova, E. Gerasimova, G. Ziyatdinova, A. Hermann, G. Sitdikova // Biomolecules. - 2020. - V. 10. - � 7. - Article 995. - 23 p.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=237031&p_lang=2	ru_RU
dc.description.abstract	Hydrogen sulfide (H2S) is endogenously produced from sulfur containing amino acids, including homocysteine and exerts neuroprotective effects. An increase of homocysteine during pregnancy impairs fetal growth and development of the offspring due to severe oxidative stress. We analyzed the effects of the H2S donor-sodium hydrosulfide (NaHS) administered to female rats with hyperhomocysteinemia (hHcy) on behavioral impairments and levels of oxidative stress of their offspring. Rats born from females fed with control or high methionine diet, with or without H2S donor injections were investigated. Rats with maternal hHcy exhibit increased levels of total locomotor activity and anxiety, decreased muscle endurance and motor coordination, abnormalities of fine motor control, as well as reduced spatial memory and learning. Oxidative stress in brain tissues measured by activity of glutathione peroxidases and the level of malondialdehyde was higher in rats with maternal hHcy. Concentrations of H2S and the activity and expression of the H2S generating enzyme-cystathionine-beta synthase-were lower compared to the control group. Administration of the H2S donor to females with hHcy during pregnancy prevented behavioral alterations and oxidative stress of their offspring. The acquisition of behavioral together with biochemical studies will add to our knowledge about homocysteine neurotoxicity and proposes H2S as a potential agent for therapy of hHcy associated disorders.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	hydrogen sulfide (H2S)	ru_RU
dc.subject	maternal hyperhomocysteinemia (hHcy)	ru_RU
dc.subject	locomotor activity	ru_RU
dc.subject	anxiety	ru_RU
dc.subject	learning and memory	ru_RU
dc.subject	motor dysfunction	ru_RU
dc.subject	H2S production	ru_RU
dc.subject	oxidative stress	ru_RU
dc.title	Hydrogen Sulfide Alleviates Anxiety, Motor, and Cognitive Dysfunctions in Rats with Maternal Hyperhomocysteinemia via Mitigation of Oxidative Stress	ru_RU
dc.type	Articles in international journals and collections	ru_RU