KFU. Card publication. Antibacterial activity profile of miramistin in in vitro and in vivo models

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

ANTIBACTERIAL ACTIVITY PROFILE OF MIRAMISTIN IN IN VITRO AND IN VIVO MODELS

Form of presentation

Articles in international journals and collections

Year of publication

2020

Язык

английский

Authors, employees of KFU

Agafonova Mariya Nikolaevna, author

Balakin Konstantin Valerevich, author

Kazakova Renata Ruvshanovna, author

Nikitina Elena Vladimirovna, author

Shtyrlin Yuriy Grigorevich, author

Other authors

Lyubina Anna Pavlovna, author

Bibliographic description in the original language

M.N. Agafonova, R.R. Kazakova, A.P. Lubina, M.I. Zeldi, E.V. Nikitina, K.V. Balakin, Y.G. Shtyrlin. Antibacterial activity profile of miramistin in in vitro and in vivo models // Microb. Pathog. – Vol. 142. – 2020. – P.1-7. https://doi.org/10.1016/j.micpath.2020.104072.

Annotation

This paper represents a systematic study of antibacterial properties of miramistin. Another objective of this work is to evaluate and compare the exploratory performance of in vitro and in vivo protocols of antiseptics' efficacy testing using miramistin as the reference antiseptic. The results of this work provide systematic data on antibacterial efficacy of miramistin. They also underscore the need in relevant in vivo models for evaluation of antiseptics' efficacy. While the existing in vitro methods can be successfully applied at the discovery stages, it is necessary to use more realistic in vivo models at more advanced development stages. The observed selectivity reversal effect should be taken into account when carrying out the antiseptics' efficacy testing and surface disinfection procedures.

Keywords

Key words: miramistin, minimal inhibitory concentration, minimal bactericidal concentration, suspension test, metal surface test, in vivo rat skin model.

The name of the journal

Microbial Pathogenesis

URL

https://doi.org/10.1016/j.micpath.2020.104072.

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=236864&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Agafonova Mariya Nikolaevna	ru_RU
dc.contributor.author	Balakin Konstantin Valerevich	ru_RU
dc.contributor.author	Kazakova Renata Ruvshanovna	ru_RU
dc.contributor.author	Nikitina Elena Vladimirovna	ru_RU
dc.contributor.author	Shtyrlin Yuriy Grigorevich	ru_RU
dc.contributor.author	Lyubina Anna Pavlovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	M.N. Agafonova, R.R. Kazakova, A.P. Lubina, M.I. Zeldi, E.V. Nikitina, K.V. Balakin, Y.G. Shtyrlin. Antibacterial activity profile of miramistin in in vitro and in vivo models // Microb. Pathog. – Vol. 142. – 2020. – P.1-7. https://doi.org/10.1016/j.micpath.2020.104072.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=236864&p_lang=2	ru_RU
dc.description.abstract	Microbial Pathogenesis	ru_RU
dc.description.abstract	This paper represents a systematic study of antibacterial properties of miramistin. Another objective of this work is to evaluate and compare the exploratory performance of in vitro and in vivo protocols of antiseptics' efficacy testing using miramistin as the reference antiseptic. The results of this work provide systematic data on antibacterial efficacy of miramistin. They also underscore the need in relevant in vivo models for evaluation of antiseptics' efficacy. While the existing in vitro methods can be successfully applied at the discovery stages, it is necessary to use more realistic in vivo models at more advanced development stages. The observed selectivity reversal effect should be taken into account when carrying out the antiseptics' efficacy testing and surface disinfection procedures.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Key words: miramistin	ru_RU
dc.subject	minimal inhibitory concentration	ru_RU
dc.subject	minimal bactericidal concentration	ru_RU
dc.subject	suspension test	ru_RU
dc.subject	metal surface test	ru_RU
dc.subject	in vivo rat skin model.	ru_RU
dc.title	Antibacterial activity profile of miramistin in in vitro and in vivo models	ru_RU
dc.type	Articles in international journals and collections	ru_RU