| Field DC |
Value |
Language |
| dc.contributor.author |
Abdullin Timur Ildarovich |
ru_RU |
| dc.contributor.author |
Kamalov Marat Ilyasovich |
ru_RU |
| dc.contributor.author |
Nemtarev Andrey Vladimirovich |
ru_RU |
| dc.contributor.author |
Pavlyuk Anna Mikhaylovna |
ru_RU |
| dc.contributor.author |
Salakhieva Diana Vitalevna |
ru_RU |
| dc.date.accessioned |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2020-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2020 |
ru_RU |
| dc.identifier.citation |
Pavlyuk A.M. Cell-Modulating Effect of Poly (Aspartic Acid) and Its Complex with Cationic Polyaspartamide / MI Kamalov, AV Nemtarev, TI Abdullin, DV Salakhieva // BioNanoScience. -2020. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=235711&p_lang=2 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
link.springer.com
ELECTROCHEMICAL DECONTAMINATION OF IRRADIATED NUCLEAR GRAPHITE OF URANIUM-GRAPHITE NUCLEAR REACTORS
AO Pavlyuk, EV Bespala, SG Kotlyarevskii, VS Zagumennov, EV Zakharova, AG Volkova, NI Rodygina
Atomic Energy 128 (1), 2020
Work has been performed as part of the implementation of measures to reduce the hazard of irradiated graphite during the decommissioning of uranium-graphite nuclear reactors. Electrochemical decontamination is studied as a method of purifying the indicated wastes from radioactive contamination. The results of experiments on removing 60 Co, 134,137 Cs, 154 Eu, and 241 Am from the surface of irradiated graphite under different conditions are presented. It is shown that electrochemical decontamination of irradiated nuclear graphite in an acidic medium makes it possible to reduce the activity of 60 Co by a factor of 2–10 and Cs by a factor of 7–100 without gaseous products of reaction being formed.
The activity of irradiated graphite is determined by the activation of the radionuclides 3 H, 14 C, 55 Fe, 60 Co, and others, the fission products 90 Sr, 106 Ru, 125 Sb, 133 Ba, 137 Cs, 154 Eu, 155 Eu, and others, and the transuranium elements 241 Am, 243 Am, 244 Cm, and others [1, 2]. The cost of their disposal depends on the class of the wastes, which is determined by the total activity
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link.springer.com
Cell-Modulating Effect of Poly (Aspartic Acid) and Its Complex with Cationic Polyaspartamide
AM Pavlyuk, MI Kamalov, AV Nemtarev, TI Abdullin, DV Salakhieva
In this communication, poly (aspartic acid)(pAsp), its fluorescently labeled conjugate with lucifer yellow ethylenediamine (pAsp–LY), and 2, 2-dimethyl-1, 3-propanediamine-derived cationic polyaspartamide (pDmpa) were synthesized by liquidphase method. Octamer of L-aspartic acid (L-Asp8) was also obtained by solid-phase synthesis. pDmpa interacted with both pAsp and model plasmid DNA to form compact nanosized interpolymer complexes, which showed different colloidal properties. Effective cellular uptake of pAsp–LY by NIH 3T3 fibroblasts was detected by confocal microscopy. Pre-complexation of pAsp–LY with pDmpa did not noticeably increase intracellular accumulation of the conjugate. Both pAsp and L-Asp8 were found to increase viability of murine 3T3 cells and human skin fibroblasts at μg/mL concentrations according to the MTT assay (24 h). This effect was observed along with moderate prooxidant activity of the peptides in the cells according to the DCFDA fluorescence assay. The results suggest that aspartic acid-based peptides per se are capable of penetrating mammalian cells and affecting their metabolic activity. The peptides can be complexed with their cationic derivative, ie, pDmpa polyaspartamide, to develop nanosized formulations of pAsp and its conjugates. |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Cell-Modulating Effect of Poly (Aspartic Acid) and Its Complex with Cationic Polyaspartamide |
ru_RU |
| dc.type |
Articles in international journals and collections |
ru_RU |
|
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