KFU. Card publication. Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons

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FEDERAL UNIVERSITY

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FACILITATION OF SEROTONIN-INDUCED SIGNALING BY THE MIGRAINE MEDIATOR CGRP IN RAT TRIGEMINAL NEURONS

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Chumanova Arina Arkadevna, author

Other authors

Guerrero Cindy , author

Bibliographic description in the original language

Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons

Annotation

BioNanoScience

Keywords

CGRP, trigeminal nerve

The name of the journal

BioNanoScience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=235428&p_lang=2

Resource files

File name	Size (MB)	Format
F_acs.biochem.7b00258.pdf	3,17	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Chumanova Arina Arkadevna	ru_RU
dc.contributor.author	Guerrero Cindy	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=235428&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The monoamine neurotransmitter serotonin (5-HT) and the neuropeptide calcitonin gene-related peptide (CGRP) play an important role in migraine pathophysiology. To study potential interplay between 5-HT and CGRP in peripheral trigeminal nociception, we performed calcium imagining and patch clamp studies in rat trigeminal ganglia cells. We found that 5-HT activated Ca²⁺ transients in 18 % of trigeminal ganglia neurons. Exposure of trigeminal cells to CGRP significantly increased the number of 5-HT positive cells to 35 % and increased the amplitude of 5-HT-induced Ca²⁺ transients. Using patch clamp technique, we show that 37 % percent of trigeminal cells generated desensitizing membrane currents suggesting functional expression of 5-HT3 receptors. These responses were partially co-localized either with ATP-gated or capsaicin-sensitive neurons. Exposure to CGRP for 2 h increased the current density in the ATP-sensitive fraction of trigeminal neurons.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	CGRP	ru_RU
dc.subject	trigeminal nerve	ru_RU
dc.title	Facilitation of Serotonin-Induced Signaling by the Migraine Mediator CGRP in Rat Trigeminal Neurons	ru_RU
dc.type	Articles in international journals and collections	ru_RU