Kazan (Volga region) Federal University, KFU
Form of presentationArticles in international journals and collections
Year of publication2020
  • Aganova Oksana Vartanovna, author
  • Galiullina Leysan Faritovna, author
  • Klochkov Vladimir Vasilevich, author
  • Nikitina Liliya Evgenevna, author
  • Pavelev Roman Sergeevich, author
  • Starceva Valeriya Andreevna, author
  • Timerova Ayzira Flyusovna, author
  • Khodov Ilya Anatolevich, author
  • Scheidt Holger A. , author
  • Bibliographic description in the original language Nikitina L.E. Structural details on the interaction of biologically active sulfur-containing monoterpenoids with lipid membranes / L.E. Nikitina, R.S. Pavelyev, V.A. Startseva, S.V. Kiselev, L.F. Galiullina, O.V. Aganova, A.F. Timerova, S.V. Boichuk, Z.R. Azizova, V.V. Klochkov, D. Huster, I.A. Khodov, H.A. Scheidt, // J. Mol. Liq. – 2020. – V 301. – 112366.
    Annotation In this work, we propose the synthesis of new thioterpenoids of a bornane series and study the influence of these compounds on hemostasis. The results from this study suggest that among all investigated terpenoids, sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetate may be the most promising for further development due to enhanced inhibition of the spontaneous aggregation compared with isoborneol, and because of its higher solubility in water compared with ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetic acid, which has approximately the same antiaggregatory and anticoagulant properties. In accordance with one hypothesis, the distribution of the studied bioactive molecules within the cellular lipid membrane can directly influence the anticoagulant properties. In the current work, the interactions of thioterpenoids with phospholipid membranes have been studied using various NMR techniques. The findings of this study indicate that sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetateexhibits a membrane location, which is shifted somewhat in the direction of the lipid-water interface. Such a location may shield the compound from interactions with hydrophobic lipid segments. In contrast, isoborneol is more deeply immersed in the membrane. These results represent an initial step toward developing new drugs based on the synthesized thioterpenoids in order to increase the effectiveness of treatment and prevention of several human diseases accompanying disorders in the hemostasis system.
    Keywords Thioterpenoids, Isoborneol, Coagulation activity, Platelets aggregation, 1D and 2D solution-state NMR, Solid-state NMR, Model cell membranes, Molecular mechanism of coagulation activity, NOESY, DOSY
    The name of the journal Journal of Molecular Liquids
    URL https://www.sciencedirect.com/science/article/pii/S016773221935994X?via%3Dihub
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=233316&p_lang=2

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