KFU. Card publication. Ammonium-Charged Sterically Hindered Phenols with Antioxidant and Selective Anti-Gram-Positive Bacterial Activity

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FEDERAL UNIVERSITY

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AMMONIUM-CHARGED STERICALLY HINDERED PHENOLS WITH ANTIOXIDANT AND SELECTIVE ANTI-GRAM-POSITIVE BACTERIAL ACTIVITY

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Bogdanov Andrey Vladimirovich, author

Ziyatdinova Guzel Kamilevna, author

Other authors

Arsenev Maksim Vyacheslavovich, author

Bogdanov Andrey Vladimirovich, author

Bukharov Sergey Vladimirovich, author

Voloshina Aleksandra Dmitrievna, author

Iskhakova Kamilla Ravilevna, author

Kulik Nataliya Vladimirovna, author

Sapunova Anastasiya Sergeevna, author

Terekhova Nataliya Viktorovna, author

Bibliographic description in the original language

Bogdanov, A.V. Ammonium‐charged sterically hindered phenols with antioxidant and selective anti‐gram‐positive bacterial activity / A.V. Bogdanov, K.R. Iskhakova, A.D. Voloshina, A.S. Sapunova, N.V. Kulik, N.V. Terekhova, M.V. Arsenyev, G.K. Ziyatdinova, S.V. Bucharov // Chem. Biodiversity. – 2020. – V. 17. – � 5. – Article e2000147. – 8 p.

Annotation

The increase in the resistance of pathogens, in particular Staphylococcus aureus , to the action of antibiotics necessitates the search for new readily available and non‐toxic drugs. In solving this problem, phenolic acylhydrazones have high potential. In this communication, the synthesis of quaternary ammonium compounds containing a differently substituted phenolic moiety has been performed. An initial study of antimicrobial activity showed that these compounds are highly selective against S. aureus and B. cereus . The highest activity (MIC 2.0 μm ) was shown by hydrazones containing a catechol fragment. These compounds are more than 3‐fold more active against S. aureus and 3–10‐fold more active against B. cereus than norfloxacin. Low hemolytic and high antioxidant activities of all new compounds were also established.

Keywords

Hydrazones, cell membrane permeability, antimicrobial activity, antioxidant activity, hemolytic activity

The name of the journal

Chemistry and Biodiversity

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083973311&doi=10.1002%2fcbdv.202000147&partnerID=40&md5=bdafd5efb6cb57cd5e211c627d189b34

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=232630&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogdanov Andrey Vladimirovich	ru_RU
dc.contributor.author	Ziyatdinova Guzel Kamilevna	ru_RU
dc.contributor.author	Arsenev Maksim Vyacheslavovich	ru_RU
dc.contributor.author	Bogdanov Andrey Vladimirovich	ru_RU
dc.contributor.author	Bukharov Sergey Vladimirovich	ru_RU
dc.contributor.author	Voloshina Aleksandra Dmitrievna	ru_RU
dc.contributor.author	Iskhakova Kamilla Ravilevna	ru_RU
dc.contributor.author	Kulik Nataliya Vladimirovna	ru_RU
dc.contributor.author	Sapunova Anastasiya Sergeevna	ru_RU
dc.contributor.author	Terekhova Nataliya Viktorovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Bogdanov, A.V. Ammonium‐charged sterically hindered phenols with antioxidant and selective anti‐gram‐positive bacterial activity / A.V. Bogdanov, K.R. Iskhakova, A.D. Voloshina, A.S. Sapunova, N.V. Kulik, N.V. Terekhova, M.V. Arsenyev, G.K. Ziyatdinova, S.V. Bucharov // Chem. Biodiversity. – 2020. – V. 17. – � 5. – Article e2000147. – 8 p.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=232630&p_lang=2	ru_RU
dc.description.abstract	Chemistry and Biodiversity	ru_RU
dc.description.abstract	The increase in the resistance of pathogens, in particular Staphylococcus aureus , to the action of antibiotics necessitates the search for new readily available and non‐toxic drugs. In solving this problem, phenolic acylhydrazones have high potential. In this communication, the synthesis of quaternary ammonium compounds containing a differently substituted phenolic moiety has been performed. An initial study of antimicrobial activity showed that these compounds are highly selective against S. aureus and B. cereus . The highest activity (MIC 2.0 μm ) was shown by hydrazones containing a catechol fragment. These compounds are more than 3‐fold more active against S. aureus and 3–10‐fold more active against B. cereus than norfloxacin. Low hemolytic and high antioxidant activities of all new compounds were also established.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hydrazones	ru_RU
dc.subject	cell membrane permeability	ru_RU
dc.subject	antimicrobial activity	ru_RU
dc.subject	antioxidant activity	ru_RU
dc.subject	hemolytic activity	ru_RU
dc.title	Ammonium-Charged Sterically Hindered Phenols with Antioxidant and Selective Anti-Gram-Positive Bacterial Activity	ru_RU
dc.type	Articles in international journals and collections	ru_RU