KFU. Card publication. The role of meningeal mast cells in ATP-induced nociceptive firing in trigeminal afferents. Anti-nociceptive effects of hydrogen sulfide

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THE ROLE OF MENINGEAL MAST CELLS IN ATP-INDUCED NOCICEPTIVE FIRING IN TRIGEMINAL AFFERENTS. ANTI-NOCICEPTIVE EFFECTS OF HYDROGEN SULFIDE

Form of presentation

Conference proceedings in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Ermakova Elizaveta Vladislavovna, author

Sadykova Alsu Nailovna, author

Sitdikova Guzel Faritovna, author

Shaydullova Kseniya Sergeevna, author

Bibliographic description in the original language

Guzel Sitdikova, Ksenia Koroleva, Elizaveta Ermakova, Alsu Mustafina, Rashid Giniatullin The role of meningeal mast cells in ATP-induced nociceptive firing in trigeminal afferents. Anti-nociceptive effects of hydrogen sulfide // The 93rd Annual Meeting of the Japanese Pharmacological Society, March 16, 2020 - March 18, 2020, Session ID : 93_2-S24-2

Annotation

The 93rd Annual Meeting of the Japanese Pharmacological Society

Keywords

mast cells, ATP, hydrogen sulfide, migraine

The name of the journal

The 93rd Annual Meeting of the Japanese Pharmacological Society

URL

https://www.jstage.jst.go.jp/article/jpssuppl/93/0/93_2-S24-2/_article/-char/en

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=232347&p_lang=2

Resource files

File name	Size (MB)	Format
Abstract_printed.pdf	0,35	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ermakova Elizaveta Vladislavovna	ru_RU
dc.contributor.author	Sadykova Alsu Nailovna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Shaydullova Kseniya Sergeevna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Guzel Sitdikova, Ksenia Koroleva, Elizaveta Ermakova, Alsu Mustafina, Rashid Giniatullin The role of meningeal mast cells in ATP-induced nociceptive firing in trigeminal afferents. Anti-nociceptive effects of hydrogen sulfide // The 93rd Annual Meeting of the Japanese Pharmacological Society, March 16, 2020 - March 18, 2020, Session ID : 93_2-S24-2	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=232347&p_lang=2	ru_RU
dc.description.abstract	The 93rd Annual Meeting of the Japanese Pharmacological Society	ru_RU
dc.description.abstract	ATP is one of the most prominent algogens, increasing the firing of trigeminal nerve, underling the migraine pain. Extracellular ATP released during migraine attacks activates meningeal afferents via neuronal P2X3 receptors. In addition ATP induces meningeal mast cell degranulation releasing serotonin which further induces nerve terminal excitation via 5-HT3 receptors. Thus, serotonin can be considered as the endogenous amplifier of purinergic nociception in meninges. Hydrogen sulfide (H2S) is a member of gasotransmitters family, induces both pro- and anti-nociceptive action in different tissues. It was shown that H2S donor -sodium hydrosulfide (NaHS) transiently increased firing in trigeminal nerve by activation of TRPV1 receptors however prevented pro-nociceptive effects of ATP. Moreover, H2S decreased currents and Ca2+ responses mediated by activation of P2X3 receptors in trigeminal neurons. Moreover, incubation of meninges in NaHS decreased ATP release and prevented mast cells degranulation. It was suggested than H2S may prevent pro-nociceptive effects of ATP in trigeminal system by inhibition of P2X3 receptors and stabilizing of meningeal mast cells. The work is supported by Russian Fund of Basic Research 18-315-00256	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	mast cells	ru_RU
dc.subject	ATP	ru_RU
dc.subject	hydrogen sulfide	ru_RU
dc.subject	migraine	ru_RU
dc.title	The role of meningeal mast cells in ATP-induced nociceptive firing in trigeminal afferents. Anti-nociceptive effects of hydrogen sulfide	ru_RU
dc.type	Conference proceedings in international journals and collections	ru_RU