KFU. Card publication. In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines

KAZAN
FEDERAL UNIVERSITY

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IN VITRO CYTOTOXIC ACTIVITY OF CERTAIN SUCCULENT PLANTS AGAINST HUMAN COLON, BREAST AND LIVER CANCER CELL LINES

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Ilinskaya Olga Nikolaevna, author

Karamova Nazira Sunagatovna, author

Other authors

Ibrahim Omer , author

Orabi Mohamed , author

Abdul-Hafeez Essam , author

Bibliographic description in the original language

Abdul-Hafeez E.Y. In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines/E.Y. Abdul-Hafeez, M.A.A. Orabi, O.H.M. Ibrahim, O.N. Ilinskaya, N.S. Karamova // South African Journal of Botany. - 2020. – V. 131. – P.: 295 – 301.

Annotation

South African Journal of Botany

Keywords

Agavaceae family, cytotoxicity, MCF-7, HepG-2, Caco-2, steroidal saponins

The name of the journal

South African Journal of Botany

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=231228&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Karamova Nazira Sunagatovna	ru_RU
dc.contributor.author	Ibrahim Omer	ru_RU
dc.contributor.author	Orabi Mohamed	ru_RU
dc.contributor.author	Abdul-Hafeez Essam	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Abdul-Hafeez E.Y. In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines/E.Y. Abdul-Hafeez, M.A.A. Orabi, O.H.M. Ibrahim, O.N. Ilinskaya, N.S. Karamova // South African Journal of Botany. - 2020. – V. 131. – P.: 295 – 301.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=231228&p_lang=2	ru_RU
dc.description.abstract	South African Journal of Botany	ru_RU
dc.description.abstract	Among the plants which are determined to be a promising source of anticarcenogenic agents are members of Agavaceae family which are common in tropical and subtropical regions such as Egypt. In this study, cytotoxic activity were assessed for the methanolic extracts and fractions from five members of Agavaceae family: Sansevieria cylindrica Bojer., Polianthes tuberosa L., Sansevieria trifasciata Prain., Yucca filamentosa L. and Furcraea watsoniana Hort. against MCF-7 (breast), HepG-2 (hepatoma), and Caco-2 (colon) cancer cell lines by MTT method. The n-hexane fraction of P. tuberosa leaves extract demonstrated strong cytotoxic potential against all three cancer cell lines (CC50<20 mg/ml). The ethyl acetate fractions of Y. filamentosa and F. watsoniana leaves significantly inhibited proliferation of hepatocellular HepG-2 (CC50 = 6.21 mg/ml and 19.07 mg/ml, respectively) and intestinal epithelium Caco-2 carcinoma cells (CC50 = 18.86 mg/ml and 23.25 mg/ml, respectively). Presumably, the cytotoxic activity exhibited by n-hexane fraction of P. tuberosa, ethyl acetate fractions of Y. filamentosa and F. watsoniana may be related to the steroidal saponins that are present in these samples.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Agavaceae family	ru_RU
dc.subject	cytotoxicity	ru_RU
dc.subject	MCF-7	ru_RU
dc.subject	HepG-2	ru_RU
dc.subject	Caco-2	ru_RU
dc.subject	steroidal saponins	ru_RU
dc.title	In vitro cytotoxic activity of certain succulent plants against human colon, breast and liver cancer cell lines	ru_RU
dc.type	Articles in international journals and collections	ru_RU