KFU. Card publication. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis.

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FEDERAL UNIVERSITY

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COMPONENTS OF THE RIBOSOME BIOGENESIS PATHWAY UNDERLIE ESTABLISHMENT OF TELOMERE LENGTH SET POINT IN ARABIDOPSIS.

Form of presentation

Articles in international journals and collections

Year of publication

2020

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Authors, employees of KFU

Abdulkina Liliya Rinatovna, author

Bibliographic description in the original language

Abdulkina, L.R., Kobayashi, C., Lovell, J.T. et al. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis. Nat Commun 10, 5479 (2019). https://doi.org/10.1038/s41467-019-13448-z

Annotation

Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genes RPL5A and RPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation.

Keywords

Natural variation in plants, telomeres

The name of the journal

Nature Communications

URL

https://www.nature.com/articles/s41467-019-13448-z#data-availability

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=224070&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdulkina Liliya Rinatovna	ru_RU
dc.date.accessioned	2020-01-01T00:00:00Z	ru_RU
dc.date.available	2020-01-01T00:00:00Z	ru_RU
dc.date.issued	2020	ru_RU
dc.identifier.citation	Abdulkina, L.R., Kobayashi, C., Lovell, J.T. et al. Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis. Nat Commun 10, 5479 (2019). https://doi.org/10.1038/s41467-019-13448-z	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=224070&p_lang=2	ru_RU
dc.description.abstract	Nature Communications	ru_RU
dc.description.abstract	Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other ribosomal genes RPL5A and RPL5B establish a shorter telomere length set point than wild type. These findings indicate that evolutionarily conserved components of ribosome biogenesis and cell proliferation pathways promote telomere elongation.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Natural variation in plants	ru_RU
dc.subject	telomeres	ru_RU
dc.title	Components of the ribosome biogenesis pathway underlie establishment of telomere length set point in Arabidopsis.	ru_RU
dc.type	Articles in international journals and collections	ru_RU