Kazan (Volga region) Federal University, KFU
Form of presentationArticles in international journals and collections
Year of publication2019
  • Gazizova Guzel Rashitovna, author
  • Gusev Oleg Aleksandrovich, author
  • Shagimardanova Elena Ilyasovna, author
  • Popov Daniil , author
  • Bibliographic description in the original language Popov, DV, Makhnovskii, PA, Shagimardanova, EL, Gazizova, GR, Lysenko, EA, Gusev, OA, Vinogradova, OL Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle // American Journal of Physiology-Endocrinology and Metabolism. – 2019. Vol. 316. №. 4. P. E605-E614. https://doi.org/10.1152/ajpendo.00449.2018
    Annotation Reduction in daily activity leads to dramatic metabolic disorders, while regular aerobic exercise training is effective for preventing this problem. The purpose of this study was to identify genes that are directly related to contractile activity in human skeletal muscle, regardless of the level of fitness. Transcriptome changes after the one-legged knee extension exercise in exercised and contralateral nonexercised vastus lateralis muscle of seven men were evaluated by RNA-seq. Transcriptome change at baseline after 2 mo of aerobic training (5/wk, 1 h/day) was evaluated as well. Postexercise changes in the transcriptome of exercised muscle were associated with different factors, including circadian oscillations. To reveal transcriptome response specific for endurance-like contractile activity, differentially expressed genes between exercised and nonexercised muscle were evaluated at 1 and 4 h after the one-legged exercise. The contractile activity-specific transcriptome responses were associated only with an increase in gene expression and were regulated mainly by CREB/ATF/AP1-, MYC/MAX-, and E2F-related transcription factors. Endurance training-induced changes (an increase or decrease) in the transcriptome at baseline were more pronounced than transcriptome responses specific for acute contractile activity. Changes after training were associated with widely different biological processes than those after acute exercise and were regulated by different transcription factors (IRF- and STAT-related factors). In conclusion, adaptation to regular exercise is associated not only with a transient (over several hours) increase in expression of many contractile activity-specific genes, but also with a pronounced change (an increase or decrease) in expression of a large number of genes under baseline conditions.
    Keywords aerobic exercise; contractile activity-specific transcriptome; RNA sequencing; skeletal muscle; transcription factors
    The name of the journal American journal of physiology. Endocrinology and metabolism
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=220566&p_lang=2

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