KFU. Card publication. Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation

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UNUSUAL FOLDING OF NAPI2B TRANSPORTER EXTRAMEMBRANE DOMAIN 4 DURING MALIGNANT TRANSFORMATION

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Bogdanov Mikhail Vasilevich, author

Bulatova Leysan Faridovna, author

Ionova Nataliya Ernestovna, author

Kiyamova Ramziya Gallyamovna, author

Skripova Vera Sergeevna, author

Authors, students KFU

Reshetnikova Darya Dmitrievna, author

Bibliographic description in the original language

L. Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation // Annals of Oncology. - 2019. - 30 (suppl_9): ix122-ix130.

Annotation

Searching for specific targets in cancer diagnosis and treatment is one of the most important problems in clinical oncology. We put forward a new concept of the emergence of tumor-specific epitopes of integral membrane proteins by changing their topology under mutations, glycosylation and tumor conditions including low pH and hypoxia on the model of Na-dependent phosphate-cotransporter NaPi2b. NaPi2b (SLC34A2, NaPi-IIb, NPT2b) belongs to the SLC34A2 transporters family and is involved in maintaining phosphate homeostasis in the human body. NaPi2b express in a number of normal and malignant tissues, including ovarian, breast and triple-negative breast cancer. It is an integral membrane protein with a large extramembrane domain 4 (EMD4, 234-362 aa), 8 transmembrane domains, N - and C - ends located in the cytoplasm.

Keywords

NaPi2b, folding, cancer

The name of the journal

ANNALS OF ONCOLOGY

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=216999&p_lang=2

Resource files

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Unusual_folding_of_NaPi2b_transporter_extramembrane_domain_4_during_malignant_transformation___OncologyPRO.pdf	0,24	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogdanov Mikhail Vasilevich	ru_RU
dc.contributor.author	Bulatova Leysan Faridovna	ru_RU
dc.contributor.author	Ionova Nataliya Ernestovna	ru_RU
dc.contributor.author	Kiyamova Ramziya Gallyamovna	ru_RU
dc.contributor.author	Skripova Vera Sergeevna	ru_RU
dc.contributor.author	Reshetnikova Darya Dmitrievna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	L. Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation // Annals of Oncology. - 2019. - 30 (suppl_9): ix122-ix130.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=216999&p_lang=2	ru_RU
dc.description.abstract	ANNALS OF ONCOLOGY	ru_RU
dc.description.abstract	Searching for specific targets in cancer diagnosis and treatment is one of the most important problems in clinical oncology. We put forward a new concept of the emergence of tumor-specific epitopes of integral membrane proteins by changing their topology under mutations, glycosylation and tumor conditions including low pH and hypoxia on the model of Na-dependent phosphate-cotransporter NaPi2b. NaPi2b (SLC34A2, NaPi-IIb, NPT2b) belongs to the SLC34A2 transporters family and is involved in maintaining phosphate homeostasis in the human body. NaPi2b express in a number of normal and malignant tissues, including ovarian, breast and triple-negative breast cancer. It is an integral membrane protein with a large extramembrane domain 4 (EMD4, 234-362 aa), 8 transmembrane domains, N - and C - ends located in the cytoplasm.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NaPi2b	ru_RU
dc.subject	folding	ru_RU
dc.subject	cancer	ru_RU
dc.title	Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation	ru_RU
dc.type	Articles in international journals and collections	ru_RU