Kazan (Volga region) Federal University, KFU
Form of presentationArticles in international journals and collections
Year of publication2019
  • Zefirov Timur Lvovich, author
  • Ziyatdinova Nafisa Ilgizovna, author
  • Kupcova Anna Mikhaylovna, author
  • Faskhutdinov Lenar Ilsurovich, author
  • Khisamieva Luiza Irekovna, author
  • Bibliographic description in the original language Zefirov T.L. The Reaction of the 3-Week-Old Rats Heart to Α2-Adrenoceptors Stimulation / T.L. Zefirov, A.M. Kuptsova , L.I. Khisamieva,L.I. Faskhutdinov, N.I. Ziyatdinova // Bioscience Biotechnology Research Communication. Special Issue. – India: Society for Science and Nature (SSN). - Vol. 12. - №5. - 2019. - pp. 248-253.
    Annotation Heart development is an accurate and complex process controlled by the nervous and humoral regulation of the body. Modern literature presents a sufficient number of results on the formation, development, and growth of sympathetic and parasympathetic nerve fibers in the heart. Adrenergic regulation of cardiac activity is realized through many subtypes of adrenergic receptors (AR). In the heart of mammals and humans, α2-adrenergic receptors (α2-AR) of presynaptic membranes take part in the modulation of the release of norepinephrine, inhibiting the release of acetylcholine from cholinergic synapses, stimulating platelet aggregation, and narrowing the vessels of certain organs. In the central nervous system, activation of postsynaptic α2-adrenergic receptors causes a protective reflex, a sedative effect, and lowers blood pressure. Non-selective stimulation of α2-AR in isolated hearts of guinea pigs leads to a drop in pressure developed by the left ventricle during sympathetic stimulation. The objective of the research was to identify the effect of stimulation of α2-AR in the heart of rats during the onset of the formation of sympathetic innervation of the heart. Ex vivo experiments were performed on Langendorff-isolated hearts. In vivo experiments were performed on a holistic organism. Studies on the whole organism showed that intravenous administration of clonidine hydrochloride leads to bradycardia in 3-week-old rats. Application of the α2-adrenergic receptor antagonist - clonidine hydrochloride in experiments on a Langendorff-isolated heart of 3-week-old rats also causes a decrease in heart rate. The severity of this effect has a concentration dependence. Clonidine had a multidirectional effect on the blood supply to the heart. An agonist at a concentration of 10–9 M and 10–6 M reduces, and at a concentration of 10–8 M increases the coronary flow. Clonidine hydrochloride at a concentration of 10-7 M causes the multidirectional effects of heart circulation of 3-week-old rats. The multidirectional effect of stimulation of α2-adrenergic receptors on CF can be associated with different localization (pre- and postsynaptic) of different subtypes of α2-AR, as well as the ability of these adrenoreceptors to bind to different G-proteins.
    Keywords Alpha2-Adrenergic Receptors, Isolated Heart, Heart Rate, Coronary Flow, Sympathetic Cardiac Innervation, Rat
    The name of the journal Bioscience Biotechnology Research Communication
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=216613&p_lang=2
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