KFU. Card publication. Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation

KAZAN
FEDERAL UNIVERSITY

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UNUSUAL FOLDING OF NAPI2B TRANSPORTER EXTRAMEMBRANE DOMAIN 4 DURING MALIGNANT TRANSFORMATION

Form of presentation

Conference proceedings in Russian journals and collections

Year of publication

2019

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Authors, employees of KFU

Bogdanov Mikhail Vasilevich, author

Bulatova Leysan Faridovna, author

Ionova Nataliya Ernestovna, author

Kiyamova Ramziya Gallyamovna, author

Skripova Vera Sergeevna, author

Other authors

- - -, author

Authors, students KFU

Reshetnikova Darya Dmitrievna, author

Bibliographic description in the original language

L. Minigulova Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation / L.Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova// Annals of Oncology. - 2019. - 30 (suppl_9): ix122-ix130.

Annotation

Annals of Oncology

Keywords

NaPi2b, folding, domains, cancer

The name of the journal

Annals of Oncology

URL

https://oncologypro.esmo.org/Meeting-Resources/ESMO-Asia-Congress-2019/Unusual-folding-of-NaPi2b-transporter-extramembrane-domain-4-during-malignant-transformation

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=216454&p_lang=2

Resource files

File name	Size (MB)	Format
F_Unusual_folding_of_NaPi2b_transporter_extramembrane_domain_4_during_malignant_transformation___OncologyPRO.pdf	0,24	pdf	show / download
F_Unusual_folding_of_NaPi2b_transporter_extramembrane_domain_4_during_malignant_transformation___OncologyPRO.pdf	0,24	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Bogdanov Mikhail Vasilevich	ru_RU
dc.contributor.author	Bulatova Leysan Faridovna	ru_RU
dc.contributor.author	Ionova Nataliya Ernestovna	ru_RU
dc.contributor.author	Kiyamova Ramziya Gallyamovna	ru_RU
dc.contributor.author	Skripova Vera Sergeevna	ru_RU
dc.contributor.author	- - -	ru_RU
dc.contributor.author	Reshetnikova Darya Dmitrievna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	L. Minigulova Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation / L.Minigulova, V. Skripova, A.K. Nurgalieva, N. Ionova, D. Reshetnikova, M. Bogdanov, R. Kiyamova// Annals of Oncology. - 2019. - 30 (suppl_9): ix122-ix130.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=216454&p_lang=2	ru_RU
dc.description.abstract	Annals of Oncology	ru_RU
dc.description.abstract	Searching for specific targets in cancer diagnosis and treatment is one of the most important problems in clinical oncology. We put forward a new concept of the emergence of tumor-specific epitopes of integral membrane proteins by changing their topology under mutations, glycosylation and tumor conditions including low pH and hypoxia on the model of Na-dependent phosphate-cotransporter NaPi2b. NaPi2b (SLC34A2, NaPi-IIb, NPT2b) belongs to the SLC34A2 transporters family and is involved in maintaining phosphate homeostasis in the human body. NaPi2b express in a number of normal and malignant tissues, including ovarian, breast and triple-negative breast cancer. It is an integral membrane protein with a large extramembrane domain 4 (EMD4, 234-362 aa), 8 transmembrane domains, N - and C - ends located in the cytoplasm.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NaPi2b	ru_RU
dc.subject	folding	ru_RU
dc.subject	domains	ru_RU
dc.subject	cancer	ru_RU
dc.title	Unusual folding of NaPi2b transporter extramembrane domain 4 during malignant transformation	ru_RU
dc.type	Conference proceedings in Russian journals and collections	ru_RU