KFU. Card publication. Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties

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NANOSIZED CARRIERS FOR HYDROPHOBIC COMPOUNDS BASED ON MESOPOROUS SILICA:SYNTHESIS AND ADSORPTION PROPERTIES

Form of presentation

Articles in Russian journals and collections

Year of publication

2019

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Authors, employees of KFU

Egorova Svetlana Robertovna, author

Lamberov Aleksandr Adolfovich, author

Bibliographic description in the original language

Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties / A. R. Ibragimova, D. R. Gabdrakhmanov, A. R. Khamatgalimov, A. F. Saifina, A. T. Gubaidullin, S. R. Egorova, A. A. Lamberov, M. P. Danilaev, L. Ya. Zakharova //Russian Chemical Bulletin, International Edition. – 2019. - Vol. 68, No. 7. - pp. 1358—1365

Annotation

MCM-41 type mesoporous silica particles were obtained using a template method in an alkaline medium and cetyltrimethylammonium bromide as a matrix. The structural and adsorption characteristics of the mesoporous material were studied by dynamic light scattering, scanning electron microscopy, low-temperature adsorption—desorption of nitrogen, IR spectro scopy, and simultaneous thermal analysis. It was shown that the obtained mesoporous material possesses high porosity with the specifi c pore volume in excess of 1 cm3 g–1. It was established that the size of silica particles does not exceed 200 nm, which is a value acceptable for the penetration of drugs through cell membranes. The optimal compositions of aqueous dispersions of MCM-41 with minimal sedimentation processes were determined. A drug (indomethacin) was encapsulated into the silica pores using the precipitation method at various temperatures (40 and 60 C), the quantitative parameters of loading effi ciency were calculated. The infl uence of temperature on the encapsulation ability was demonstrated.

Keywords

template synthesis, MCM-41 type mesoporous silica, indomethacin, adsorption

The name of the journal

Russian Chemical Bulletin

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=212671&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Egorova Svetlana Robertovna	ru_RU
dc.contributor.author	Lamberov Aleksandr Adolfovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties / A. R. Ibragimova, D. R. Gabdrakhmanov, A. R. Khamatgalimov, A. F. Saifina, A. T. Gubaidullin, S. R. Egorova, A. A. Lamberov, M. P. Danilaev, L. Ya. Zakharova //Russian Chemical Bulletin, International Edition. – 2019. - Vol. 68, No. 7. - pp. 1358—1365	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=212671&p_lang=2	ru_RU
dc.description.abstract	Russian Chemical Bulletin	ru_RU
dc.description.abstract	MCM-41 type mesoporous silica particles were obtained using a template method in an alkaline medium and cetyltrimethylammonium bromide as a matrix. The structural and adsorption characteristics of the mesoporous material were studied by dynamic light scattering, scanning electron microscopy, low-temperature adsorption—desorption of nitrogen, IR spectro scopy, and simultaneous thermal analysis. It was shown that the obtained mesoporous material possesses high porosity with the specifi c pore volume in excess of 1 cm3 g–1. It was established that the size of silica particles does not exceed 200 nm, which is a value acceptable for the penetration of drugs through cell membranes. The optimal compositions of aqueous dispersions of MCM-41 with minimal sedimentation processes were determined. A drug (indomethacin) was encapsulated into the silica pores using the precipitation method at various temperatures (40 and 60 C), the quantitative parameters of loading effi ciency were calculated. The infl uence of temperature on the encapsulation ability was demonstrated.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	template synthesis	ru_RU
dc.subject	MCM-41 type mesoporous silica	ru_RU
dc.subject	indomethacin	ru_RU
dc.subject	adsorption	ru_RU
dc.title	Nanosized carriers for hydrophobic compounds based on mesoporous silica:synthesis and adsorption properties	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU