KFU. Card publication. DOI 10.1007/s12668-018-0528-1

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

DOI 10.1007/S12668-018-0528-1

Form of presentation

Articles in international journals and collections

Year of publication

2018

Authors, employees of KFU

Abdulkhakov Sayyar Rustamovich, author

Laykov Aleksandr Vladimirovich, author

Other authors

Zayceva T.A., Medvedeva S.N.

Authors, postgraduates KFU

Lopukhov Viktor Leonidovich, postgraduate kfu

Bibliographic description in the original language

LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine

Annotation

The negative impact of tobacco smoke on the human body is due to a wide range of harmful substances including volatile organic compounds (VOCs). Some VOCs of tobacco smoke metabolize in human organism into mercapturic acids (MAs). The determination of the amount of MAs in readily available biological fluids, for example in urine, allows to assess the level of exposure of these VOCs in a particular person. It is useful to assess the impact of individual VOCs on the body together with the assessment of the intake of nicotine. The intake of nicotine can be determined by the content of its metabolites in the urine, in particular by the content of trans-3′-hydroxycotinine (tH-Cot). A joint assessment of the concentrations of trans-3′-hydroxycotinine and MAs in urine allows obtaining selective information about effects of different VOCs and nicotine on the smoker?s body. We have developed a liquid chromatography?mass spectrometry (LC-MS) method for simultaneous quantifying of tH-Cot

Keywords

Mercapturic acids, Nicotine, Tobacco, LC-MS

The name of the journal

BioNanoScience

URL

https://link.springer.com/article/10.1007%2Fs12668-018-0528-1

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=211141&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdulkhakov Sayyar Rustamovich	ru_RU
dc.contributor.author	Laykov Aleksandr Vladimirovich	ru_RU
dc.contributor.author	Lopukhov Viktor Leonidovich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	LC-MS Method Development for Simultaneous Determination of Trans-3′-hydroxycotinine and Three Mercapturic Acids in Urine	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=211141&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	The negative impact of tobacco smoke on the human body is due to a wide range of harmful substances including volatile organic compounds (VOCs). Some VOCs of tobacco smoke metabolize in human organism into mercapturic acids (MAs). The determination of the amount of MAs in readily available biological fluids, for example in urine, allows to assess the level of exposure of these VOCs in a particular person. It is useful to assess the impact of individual VOCs on the body together with the assessment of the intake of nicotine. The intake of nicotine can be determined by the content of its metabolites in the urine, in particular by the content of trans-3′-hydroxycotinine (tH-Cot). A joint assessment of the concentrations of trans-3′-hydroxycotinine and MAs in urine allows obtaining selective information about effects of different VOCs and nicotine on the smoker?s body. We have developed a liquid chromatography?mass spectrometry (LC-MS) method for simultaneous quantifying of tH-Cot	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Mercapturic acids	ru_RU
dc.subject	Nicotine	ru_RU
dc.subject	Tobacco	ru_RU
dc.subject	LC-MS	ru_RU
dc.title	DOI 10.1007/s12668-018-0528-1	ru_RU
dc.type	Articles in international journals and collections	ru_RU