KFU. Card publication. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing

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FEDERAL UNIVERSITY

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ISOFORMS OF BASE EXCISION REPAIR ENZYMES PRODUCED BY ALTERNATIVE SPLICING

Form of presentation

Articles in international journals and collections

Year of publication

2019

Язык

английский

Authors, employees of KFU

Khayrullin Rafil Fidailevich, author

Other authors

Boldinova Elizaveta , author

Bibliographic description in the original language

Boldinova, E.O.; Khairullin, R.F.; Makarova, A.V.; Zharkov, D.O. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing. Int. J. Mol. Sci. 2019, 20, 3279.

Annotation

Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.

Keywords

alternative splicing, DNA glycosylases, apurinic/apyrimidinic endonuclease, DNA polymerase beta

The name of the journal

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

URL

https://www.mdpi.com/1422-0067/20/13/3279

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=205340&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Khayrullin Rafil Fidailevich	ru_RU
dc.contributor.author	Boldinova Elizaveta	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Boldinova, E.O.; Khairullin, R.F.; Makarova, A.V.; Zharkov, D.O. Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing. Int. J. Mol. Sci. 2019, 20, 3279.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=205340&p_lang=2	ru_RU
dc.description.abstract	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	ru_RU
dc.description.abstract	Transcripts of many enzymes involved in base excision repair (BER) undergo extensive alternative splicing, but functions of the corresponding alternative splice variants remain largely unexplored. In this review, we cover the studies describing the common alternatively spliced isoforms and disease-associated variants of DNA glycosylases, AP-endonuclease 1, and DNA polymerase beta. We also discuss the roles of alternative splicing in the regulation of their expression, catalytic activities, and intracellular transport.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	alternative splicing	ru_RU
dc.subject	DNA glycosylases	ru_RU
dc.subject	apurinic/apyrimidinic endonuclease	ru_RU
dc.subject	DNA polymerase beta	ru_RU
dc.title	Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing	ru_RU
dc.type	Articles in international journals and collections	ru_RU