KFU. Card publication. Interfacial uploading of luminescent hexamolybdenum cluster units onto amino-decorated silica nanoparticles as new design of nanomaterial for cellular imaging and photodynamic therapy

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INTERFACIAL UPLOADING OF LUMINESCENT HEXAMOLYBDENUM CLUSTER UNITS ONTO AMINO-DECORATED SILICA NANOPARTICLES AS NEW DESIGN OF NANOMATERIAL FOR CELLULAR IMAGING AND PHOTODYNAMIC THERAPY

Form of presentation

Articles in international journals and collections

Year of publication

2019

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Authors, employees of KFU

Miftakhova Regina Rifkatovna, author

Rizvanov Albert Anatolevich, author

Other authors

Mustafina Asiya Rafaelevna, author

Bibliographic description in the original language

Elistratova, J., A. Mukhametshina, K. Kholin, I. Nizameev, M. Mikhailov, M. Sokolov, R. Khairullin, R. Miftakhova, G. Shammas, M. Kadirov, K. Petrov, A. Rizvanov and A. Mustafina (2019). «Interfacial uploading of luminescent hexamolybdenum cluster units onto amino-decorated silica nanoparticles as new design of nanomaterial for cellular imaging and photodynamic therapy.« J Colloid Interface Sci 538: 387-396.

Annotation

The present work introduces a facile synthetic route to embed phosphorescent K2[{Mo6I8}I6] and (nBu4N)2[{Mo6I8}(CH3COO)6] clusters (C) onto silica-water interface of amino-decorated silica nanoparticles (SNs, 60 ? 6 nm). The assembled C-SNs gain in the luminescence intensity, which remains stable within three months after their assembly. High uptake capacity of the clusters (8700 of K2[{Mo6I8}I6] and 6500 of (nBu4N)2[{Mo6I8}(CH3COO)6] per the each nanoparticle) derives from ionic self-assembly and coordination bonds between the cluster complexes and ionic (amino- and siloxy-) groups at the silica surface. The coordination via amino- or siloxy-groups restricts aquation and hydrolysis of the embedded clusters, in comparison with the parent K2[{Mo6I8}I6] and (nBu4N)2[{Mo6I8}(CH3COO)6. High potential of the assembled nanoparticles in the ROS generation was revealed by EPR measurements facilitated by spin trapping. The high positive charge and convenient colloid stability of the assembled C-SNs hybrids are the prerequisite for their efficient cellular uptake, which is exemplified in the work by MCF-7 cell line. The measured dark and photoinduced cytotoxicity of the C-SNs hybrids reveals significant photodynamic therapy effect on the MCF-7 cancer cell line versus the normal cells. This effect is entirely due to the embedded clusters and is dependent on the chemical composition of the cluster.

Keywords

photodynamic therapy, silica nanoparticles, hexamolybdenum clusters

The name of the journal

Journal of Colloid and Interface Science

URL

https://www.sciencedirect.com/science/article/pii/S0021979718314474?via%3Dihub

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=204072&p_lang=2

Resource files

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1_s2.0_S0021979718314474_main.pdf	1,87	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Miftakhova Regina Rifkatovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Mustafina Asiya Rafaelevna	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Elistratova, J., A. Mukhametshina, K. Kholin, I. Nizameev, M. Mikhailov, M. Sokolov, R. Khairullin, R. Miftakhova, G. Shammas, M. Kadirov, K. Petrov, A. Rizvanov and A. Mustafina (2019). «Interfacial uploading of luminescent hexamolybdenum cluster units onto amino-decorated silica nanoparticles as new design of nanomaterial for cellular imaging and photodynamic therapy.« J Colloid Interface Sci 538: 387-396.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=204072&p_lang=2	ru_RU
dc.description.abstract	Journal of Colloid and Interface Science	ru_RU
dc.description.abstract	The present work introduces a facile synthetic route to embed phosphorescent K2[{Mo6I8}I6] and (nBu4N)2[{Mo6I8}(CH3COO)6] clusters (C) onto silica-water interface of amino-decorated silica nanoparticles (SNs, 60 ? 6 nm). The assembled C-SNs gain in the luminescence intensity, which remains stable within three months after their assembly. High uptake capacity of the clusters (8700 of K2[{Mo6I8}I6] and 6500 of (nBu4N)2[{Mo6I8}(CH3COO)6] per the each nanoparticle) derives from ionic self-assembly and coordination bonds between the cluster complexes and ionic (amino- and siloxy-) groups at the silica surface. The coordination via amino- or siloxy-groups restricts aquation and hydrolysis of the embedded clusters, in comparison with the parent K2[{Mo6I8}I6] and (nBu4N)2[{Mo6I8}(CH3COO)6. High potential of the assembled nanoparticles in the ROS generation was revealed by EPR measurements facilitated by spin trapping. The high positive charge and convenient colloid stability of the assembled C-SNs hybrids are the prerequisite for their efficient cellular uptake, which is exemplified in the work by MCF-7 cell line. The measured dark and photoinduced cytotoxicity of the C-SNs hybrids reveals significant photodynamic therapy effect on the MCF-7 cancer cell line versus the normal cells. This effect is entirely due to the embedded clusters and is dependent on the chemical composition of the cluster.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	photodynamic therapy	ru_RU
dc.subject	silica nanoparticles	ru_RU
dc.subject	hexamolybdenum clusters	ru_RU
dc.title	Interfacial uploading of luminescent hexamolybdenum cluster units onto amino-decorated silica nanoparticles as new design of nanomaterial for cellular imaging and photodynamic therapy	ru_RU
dc.type	Articles in international journals and collections	ru_RU