KFU. Card publication. Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery

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TRANSPLANTATION OF MICROGLIA IN THE AREA OF SPINAL CORD INJURY IN AN ACUTE PERIOD INCREASES TISSUE SPARING, BUT NOT FUNCTIONAL RECOVERY

Form of presentation

Articles in international journals and collections

Year of publication

2018

Authors, employees of KFU

Akhmetzyanova Elvira Ruslanovna, author

Garanina Ekaterina Evgenevna, author

Zhuravleva Margarita Nikolaevna, author

Kostennikov Aleksandr Aleksandrovich, author

Mukhamedshina Yana Olegovna, author

Rizvanov Albert Anatolevich, author

Other authors

Galieva Luiza Ramilevna

Authors, postgraduates KFU

Akhmetzyanova Elvira Ruslanovna, postgraduate kfu

Bibliographic description in the original language

Akhmetzyanova, E. R., Mukhamedshina, Y. O., Zhuravleva, M. N., Galieva, L. R., Kostennikov, A. A., Garanina, E. E., & Rizvanov, A. A. (2018). Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery. Frontiers in cellular neuroscience, 12, 507. doi:10.3389/fncel.2018.00507

Annotation

Microglial cells are known as important mediators of inflammation and immune response in the central nervous system (CNS). However, a neuroprotective role of these cells in post-traumatic processes should not be overlooked. Microglial cells are the first to respond to CNS injury and are further involved in all critical events of pathogenesis. When activated microglia clear the cellular debris and release anti- and proinflammatory cytokines and chemokines, nitric oxide, neurotrophins, and antioxidants capable of producing both neurotoxic and neuroprotective effects. The aim of this study was to determine to what extent the phagocytic activity of microglia in an acute period of spinal cord injury (SCI) in rats can effect the post-traumatic processes. For this purpose we implanted genetically modified Ad5-EGFP or Ad5-GDNF microglial cells into the area of acute SCI.

Keywords

microglia, spinal cord injury, egfp, gdnf, adenoviral vector

Place of publication

��

The name of the journal

Frontiers in Cellular Neuroscience

Publishing house

Frontiers

URL

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315181/

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=203907&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.contributor.author	Garanina Ekaterina Evgenevna	ru_RU
dc.contributor.author	Zhuravleva Margarita Nikolaevna	ru_RU
dc.contributor.author	Kostennikov Aleksandr Aleksandrovich	ru_RU
dc.contributor.author	Mukhamedshina Yana Olegovna	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Akhmetzyanova Elvira Ruslanovna	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Akhmetzyanova, E. R., Mukhamedshina, Y. O., Zhuravleva, M. N., Galieva, L. R., Kostennikov, A. A., Garanina, E. E., & Rizvanov, A. A. (2018). Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery. Frontiers in cellular neuroscience, 12, 507. doi:10.3389/fncel.2018.00507	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=203907&p_lang=2	ru_RU
dc.description.abstract	Frontiers in Cellular Neuroscience	ru_RU
dc.description.abstract	Microglial cells are known as important mediators of inflammation and immune response in the central nervous system (CNS). However, a neuroprotective role of these cells in post-traumatic processes should not be overlooked. Microglial cells are the first to respond to CNS injury and are further involved in all critical events of pathogenesis. When activated microglia clear the cellular debris and release anti- and proinflammatory cytokines and chemokines, nitric oxide, neurotrophins, and antioxidants capable of producing both neurotoxic and neuroprotective effects. The aim of this study was to determine to what extent the phagocytic activity of microglia in an acute period of spinal cord injury (SCI) in rats can effect the post-traumatic processes. For this purpose we implanted genetically modified Ad5-EGFP or Ad5-GDNF microglial cells into the area of acute SCI.	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	Frontiers	ru_RU
dc.subject	microglia	ru_RU
dc.subject	spinal cord injury	ru_RU
dc.subject	egfp	ru_RU
dc.subject	gdnf	ru_RU
dc.subject	adenoviral vector	ru_RU
dc.title	Transplantation of Microglia in the Area of Spinal Cord Injury in an Acute Period Increases Tissue Sparing, but Not Functional Recovery	ru_RU
dc.type	Articles in international journals and collections	ru_RU