KFU. Card publication. NMR screening and studies of target

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

NMR SCREENING AND STUDIES OF TARGET&NDASH;LIGAND INTERACTIONS

Form of presentation

Articles in international journals and collections

Year of publication

2019

Язык

русский

Authors, employees of KFU

Polshakov Vladimir Ivanovich, author

Other authors

Batuev Evgeniy Andreevich, author

Mancyzov Aleksey Borisovich, author

Bibliographic description in the original language

Polshakov, V. I., Batuev, E. A., & Mantsyzov, A. B. (2019). NMR screening and studies of target–ligand interactions. Russian Chemical Reviews, 88(1), 59.

Annotation

Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs.

Keywords

NMR spectroscopy, protein-ligand interaction, NMR screening, biological targets, physiologically active compounds, rational drug design, fragment-based lead design, structure-activity relationship

The name of the journal

RUSSIAN CHEMICAL REVIEWS

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/149808/2019_RusChemRev_1stpage_refs.pdf?sequence=1&isAllowed=y

URL

https://iopscience.iop.org/article/10.1070/RCR4836/meta

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=195615&p_lang=2

Resource files

File name	Size (MB)	Format
2019_RusChemRev_1stpage_refs.pdf	0,22	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Polshakov Vladimir Ivanovich	ru_RU
dc.contributor.author	Batuev Evgeniy Andreevich	ru_RU
dc.contributor.author	Mancyzov Aleksey Borisovich	ru_RU
dc.date.accessioned	2019-01-01T00:00:00Z	ru_RU
dc.date.available	2019-01-01T00:00:00Z	ru_RU
dc.date.issued	2019	ru_RU
dc.identifier.citation	Polshakov, V. I., Batuev, E. A., & Mantsyzov, A. B. (2019). NMR screening and studies of target–ligand interactions. Russian Chemical Reviews, 88(1), 59.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=195615&p_lang=2	ru_RU
dc.description.abstract	RUSSIAN CHEMICAL REVIEWS	ru_RU
dc.description.abstract	Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NMR spectroscopy	ru_RU
dc.subject	protein-ligand interaction	ru_RU
dc.subject	NMR screening	ru_RU
dc.subject	biological targets	ru_RU
dc.subject	physiologically active compounds	ru_RU
dc.subject	rational drug design	ru_RU
dc.subject	fragment-based lead design	ru_RU
dc.subject	structure-activity relationship	ru_RU
dc.title	NMR screening and studies of target–ligand interactions	ru_RU
dc.type	Articles in international journals and collections	ru_RU