KFU. Card publication. Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology

KAZAN
FEDERAL UNIVERSITY

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CASCADE REACTION IN HUMAN LIVE TISSUE ALLOWS CLINICALLY APPLICABLE DIAGNOSIS OF BREAST CANCER MORPHOLOGY

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Kurbangalieva Almira Rafaelovna, author

Saygitbatalova Elena Shiripovna, author

Tanaka Kacunori , author

Authors, postgraduates KFU

Saygitbatalova Elena Shiripovna, postgraduate kfu

Bibliographic description in the original language

Tanei, T. Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology / T. Tanei, A. R. Pradipta, K. Morimoto, M. Fujii, M. Arata, A. Ito, M. Yoshida, E. Saigitbatalova, A. Kurbangalieva, J. Ikeda, E. Morii, S. Noguchi, K. Tanaka // Adv. Sci. ? 2018. ? Article � 1801479.

Annotation

Clean operating margins in breast cancer surgery are important for preventing recurrence. However, the current methods for determining margins such as intraoperative frozen section analysis or imprint cytology are not satisfactory since they are time-consuming and cause a burden on the patient and on hospitals with a limited accuracy. A ?click-to-sense? probe is developed based on the detection of acrolein, which is a substance released by oxidatively stressed cancer cells and can be visualized under fluorescence microscopy. Using live breast tissues resected from breast cancer patients, it is demonstrated that this method can quickly, selectively, and sensitively differentiate cancer lesion from normal breast gland or benign proliferative lesions. Since acrolein is accumulated in all types of cancers, this method could be used to quickly assess the surgical margins in other types of cancer.

Keywords

Acrolein, breast cancer, "click-to-sense" probe, oxidative stress, fluorescence microscopy

The name of the journal

Advanced Science

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057300739&doi=10.1002%2fadvs.201801479&partnerID=40&md5=fc3c552d75cc51d5ff5daa6465de6073

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=191578&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.contributor.author	Tanaka Kacunori	ru_RU
dc.contributor.author	Saygitbatalova Elena Shiripovna	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Tanei, T. Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology / T. Tanei, A. R. Pradipta, K. Morimoto, M. Fujii, M. Arata, A. Ito, M. Yoshida, E. Saigitbatalova, A. Kurbangalieva, J. Ikeda, E. Morii, S. Noguchi, K. Tanaka // Adv. Sci. ? 2018. ? Article � 1801479.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=191578&p_lang=2	ru_RU
dc.description.abstract	Advanced Science	ru_RU
dc.description.abstract	Clean operating margins in breast cancer surgery are important for preventing recurrence. However, the current methods for determining margins such as intraoperative frozen section analysis or imprint cytology are not satisfactory since they are time-consuming and cause a burden on the patient and on hospitals with a limited accuracy. A ?click-to-sense? probe is developed based on the detection of acrolein, which is a substance released by oxidatively stressed cancer cells and can be visualized under fluorescence microscopy. Using live breast tissues resected from breast cancer patients, it is demonstrated that this method can quickly, selectively, and sensitively differentiate cancer lesion from normal breast gland or benign proliferative lesions. Since acrolein is accumulated in all types of cancers, this method could be used to quickly assess the surgical margins in other types of cancer.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Acrolein	ru_RU
dc.subject	breast cancer	ru_RU
dc.subject	"click-to-sense" probe	ru_RU
dc.subject	oxidative stress	ru_RU
dc.subject	fluorescence microscopy	ru_RU
dc.title	Cascade reaction in human live tissue allows clinically applicable diagnosis of breast cancer morphology	ru_RU
dc.type	Articles in international journals and collections	ru_RU