KFU. Card publication. Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation

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NOVEL WATER-SOLUBLE METHANOFULLERENES C 60 [C 13 H 18 O 4 (OH) 4] 6 AND C 60 [C 9 H 10 O 4 (OH) 4] 6: PROMISING UNCOUPLERS OF RESPIRATION AND PHOSPHORYLATION

Form of presentation

Articles in international journals and collections

Year of publication

2015

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Authors, employees of KFU

Kalacheva Nataliya Vasilevna, author

Bibliographic description in the original language

Kalacheva N. Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation / Kalacheva NV, Gubskaya VP, Fazleeva GM, Igtisamova GR, Nuretdinov IA, Rizvanov AA, Cherepnev GV // Bioorganic & medicinal chemistry letters.- 2015.- Vol.25 – P. 5250–5253.

Annotation

Here, we report for the first time on two novel water-soluble polyol-methanofullerenes which uncouple respiration and oxidative phosphorylation. A cytofluorimetric JC-1-based ratiometric assay was used to quantify mitochondrial potential Wm in Yarrowia lipolytica cells exposed to the fullerenes tested. Both methanofullerenes significantly downregulated Wm, thereby decreasing the subset of cells with high mitochondrial potential compared with intact control cells. The Wm-low subset of Yarrowia lipolytica cells resulted from methanofullerenes exposure preserved physiological cell size and granularity patterns.

Keywords

Water-soluble methanofullerenes Mitochondrial transmembrane potential Uncouplers of oxidative phosphorylation

The name of the journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=191442&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kalacheva Nataliya Vasilevna	ru_RU
dc.date.accessioned	2015-01-01T00:00:00Z	ru_RU
dc.date.available	2015-01-01T00:00:00Z	ru_RU
dc.date.issued	2015	ru_RU
dc.identifier.citation	Kalacheva N. Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation / Kalacheva NV, Gubskaya VP, Fazleeva GM, Igtisamova GR, Nuretdinov IA, Rizvanov AA, Cherepnev GV // Bioorganic & medicinal chemistry letters.- 2015.- Vol.25 – P. 5250–5253.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=191442&p_lang=2	ru_RU
dc.description.abstract	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS	ru_RU
dc.description.abstract	Here, we report for the first time on two novel water-soluble polyol-methanofullerenes which uncouple respiration and oxidative phosphorylation. A cytofluorimetric JC-1-based ratiometric assay was used to quantify mitochondrial potential Wm in Yarrowia lipolytica cells exposed to the fullerenes tested. Both methanofullerenes significantly downregulated Wm, thereby decreasing the subset of cells with high mitochondrial potential compared with intact control cells. The Wm-low subset of Yarrowia lipolytica cells resulted from methanofullerenes exposure preserved physiological cell size and granularity patterns.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Novel water-soluble methanofullerenes C 60 [C 13 H 18 O 4 (OH) 4] 6 and C 60 [C 9 H 10 O 4 (OH) 4] 6: Promising uncouplers of respiration and phosphorylation	ru_RU
dc.type	Articles in international journals and collections	ru_RU