KFU. Card publication. Self-assembled nanoformulation of methylprednisolone succinate with carboxylated block copolymer for local glucocorticoid therapy

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SELF-ASSEMBLED NANOFORMULATION OF METHYLPREDNISOLONE SUCCINATE WITH CARBOXYLATED BLOCK COPOLYMER FOR LOCAL GLUCOCORTICOID THERAPY

Form of presentation

International monographs

Year of publication

2018

Authors, employees of KFU

Abdullin Timur Ildarovich, author

Authors, students KFU

Dang Tkhi Vet Chin , author

Bibliographic description in the original language

A new formulation of methylprednisolone succinate (MPS) with pre-oxidized carboxylated trifunctional block copolymer of ethylene oxide (EO) and propylene oxide (PO) (TBC?COOH) has been developed. TBC?COOH aggregates are spontaneously rearranged by MPS producing highly homogeneous mixed micelles (TBC?COOH/MPS) with hydrodynamic diameter of 19.6?0.3 nm, zeta potential of ?27.8?3.2 mV (pH 7.0) and with optimal weight ratio 1:6.3. The role of polypropylene oxide component in a copolymer and methylprednisolone succinylation in forming the mixed micelles was studied by comparing copolymers and corticosteroids of different structure. Micellar structure TBC?COOH/MPS is highly resistant to a dilution, temperature fluctuations and the presence of blood serum components. TBC?COOH promotes intrinsic cytotoxicity of increased concentrations of MPS for SH-SY5Y and PC-12 cells after 7-hour exposure attributed to enhanced cellular availability of the mixed micelles

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=188799&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdullin Timur Ildarovich	ru_RU
dc.contributor.author	Dang Tkhi Vet Chin	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	A new formulation of methylprednisolone succinate (MPS) with pre-oxidized carboxylated trifunctional block copolymer of ethylene oxide (EO) and propylene oxide (PO) (TBC?COOH) has been developed. TBC?COOH aggregates are spontaneously rearranged by MPS producing highly homogeneous mixed micelles (TBC?COOH/MPS) with hydrodynamic diameter of 19.6?0.3 nm, zeta potential of ?27.8?3.2 mV (pH 7.0) and with optimal weight ratio 1:6.3. The role of polypropylene oxide component in a copolymer and methylprednisolone succinylation in forming the mixed micelles was studied by comparing copolymers and corticosteroids of different structure. Micellar structure TBC?COOH/MPS is highly resistant to a dilution, temperature fluctuations and the presence of blood serum components. TBC?COOH promotes intrinsic cytotoxicity of increased concentrations of MPS for SH-SY5Y and PC-12 cells after 7-hour exposure attributed to enhanced cellular availability of the mixed micelles	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=188799&p_lang=2	ru_RU
dc.language.iso	ru	ru_RU
dc.title	Self-assembled nanoformulation of methylprednisolone succinate with carboxylated block copolymer for local glucocorticoid therapy	ru_RU
dc.type	International monographs	ru_RU