KFU. Card publication. Evaluation of skin irritation in rats using simultaneous laser Doppler flowmetry and oxygenation monitoring

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

EVALUATION OF SKIN IRRITATION IN RATS USING SIMULTANEOUS LASER DOPPLER FLOWMETRY AND OXYGENATION MONITORING

Form of presentation

Articles in international journals and collections

Year of publication

2016

Authors, employees of KFU

Abdullin Timur Ildarovich, author

Authors, students KFU

Dang Tkhi Vet Chin , author

Bibliographic description in the original language

The possibility of assessment of skin irritation in rats with the use of simultaneous laser Doppler flowmetry (LDF) and oxygenation monitoring was investigated. The study was designed according to ISO 10993-10 using formaldehyde as a model irritant. 4-Hour application of 1 % formaldehyde induced significant local increase in skin microcirculation for the first 2 days by a factor of up to 2.4, whereas tissue oxygenation increased in much lower extent. The microcirculation was significantly inhibited by 10 % formaldehyde following treatment and then it gradually increased for 24 and 48 h of recovery period. The results correlated with visual evaluation of skin edema and erythema in treated zones. LDF/oxygenation signals provide early information on skin irritation and damage in rat model. The technique is valuable for preclinical/toxicological studies of chemical substances and medical materials.

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=188797&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Abdullin Timur Ildarovich	ru_RU
dc.contributor.author	Dang Tkhi Vet Chin	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	The possibility of assessment of skin irritation in rats with the use of simultaneous laser Doppler flowmetry (LDF) and oxygenation monitoring was investigated. The study was designed according to ISO 10993-10 using formaldehyde as a model irritant. 4-Hour application of 1 % formaldehyde induced significant local increase in skin microcirculation for the first 2 days by a factor of up to 2.4, whereas tissue oxygenation increased in much lower extent. The microcirculation was significantly inhibited by 10 % formaldehyde following treatment and then it gradually increased for 24 and 48 h of recovery period. The results correlated with visual evaluation of skin edema and erythema in treated zones. LDF/oxygenation signals provide early information on skin irritation and damage in rat model. The technique is valuable for preclinical/toxicological studies of chemical substances and medical materials.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=188797&p_lang=2	ru_RU
dc.language.iso	ru	ru_RU
dc.title	Evaluation of skin irritation in rats using simultaneous laser Doppler flowmetry and oxygenation monitoring	ru_RU
dc.type	Articles in international journals and collections	ru_RU