KFU. Card publication. Effect Of α1A-Adrenergic Receptors Stimulation To The Isolated Rat Hearts Chronotropy

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FEDERAL UNIVERSITY

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EFFECT OF α1A-ADRENERGIC RECEPTORS STIMULATION TO THE ISOLATED RAT HEARTS CHRONOTROPY

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Kupcova Anna Mikhaylovna, author

Khabibrakhmanov Insaf Ilkhamovich, author

Bibliographic description in the original language

Khabibrakhmanov I.I. Effect Of α1A-Adrenergic Receptors Stimulation To The Isolated Rat Hearts Chronotropy/ I.I. Khabibrakhmanov, N.I. Ziyatdinova, A.M. Kuptsova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 2018. - Vol. 9(6). - P. 525-529.

Annotation

Bradycardia of the heart in response to the selective activation of α1A-AR in in vivo experiments was short-term and was replaced by an increase in frequency, which may be due to the activation of the reflex compensatory mechanisms of the organism. However, the chronotropic effects of selective stimulation of α1A-adrenergic receptors directly on the isolated heart in ex vivo experiments have not been revealed. The results obtained may indicate that this subtype of α1-adrenergic receptors is not involved in the regulation of heart rate. The change in heart rate in in vivo experiments is most likely due to the reflex mechanisms of regulation of the functioning of the rat heart, as well as changes in the vascular tone.

Keywords

α1-adrenergic receptors, chronotropy, heart, rat

The name of the journal

RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES

URL

http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=2&SID=D6asvkjJmm9WpzRsidq&page=7&doc=65

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=188495&p_lang=2

Resource files

File name	Size (MB)	Format
alfa_1_khron_Insaf_2018.pdf	0,29	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Kupcova Anna Mikhaylovna	ru_RU
dc.contributor.author	Khabibrakhmanov Insaf Ilkhamovich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Khabibrakhmanov I.I. Effect Of α1A-Adrenergic Receptors Stimulation To The Isolated Rat Hearts Chronotropy/ I.I. Khabibrakhmanov, N.I. Ziyatdinova, A.M. Kuptsova, T.L. Zefirov //Research Journal of Pharmaceutical, Biological and Chemical Sciences. - 2018. - Vol. 9(6). - P. 525-529.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=188495&p_lang=2	ru_RU
dc.description.abstract	RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES	ru_RU
dc.description.abstract	Bradycardia of the heart in response to the selective activation of α1A-AR in in vivo experiments was short-term and was replaced by an increase in frequency, which may be due to the activation of the reflex compensatory mechanisms of the organism. However, the chronotropic effects of selective stimulation of α1A-adrenergic receptors directly on the isolated heart in ex vivo experiments have not been revealed. The results obtained may indicate that this subtype of α1-adrenergic receptors is not involved in the regulation of heart rate. The change in heart rate in in vivo experiments is most likely due to the reflex mechanisms of regulation of the functioning of the rat heart, as well as changes in the vascular tone.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	α1-adrenergic receptors	ru_RU
dc.subject	chronotropy	ru_RU
dc.subject	heart	ru_RU
dc.subject	rat	ru_RU
dc.title	Effect Of α1A-Adrenergic Receptors Stimulation To The Isolated Rat Hearts Chronotropy	ru_RU
dc.type	Articles in international journals and collections	ru_RU