KFU. Card publication. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles

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NMR STUDY OF CONFORMATIONAL STRUCTURE OF FLUVASTATIN AND ITS COMPLEX WITH DODECYLPHOSPHOCHOLINE MICELLES

Form of presentation

Articles in international journals and collections

Year of publication

2016

Authors, employees of KFU

Aganov Albert Vartanovich, author

Galiullina Leysan Faritovna, author

Klochkov Vladimir Vasilevich, author

Latfullin Ildus Anvarovich, author

Authors, postgraduates KFU

Musabirova Guzel Salavatovna, postgraduate kfu

Bibliographic description in the original language

L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles // BioNanoScience, V. 6, 2016.-P. 352-354.

Annotation

Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.

Keywords

Nuclear magnetic resonance, Fluvastatin, Micelles, Molecular complex

The name of the journal

BioNanoScience

URL

https://doi.org/10.1016/j.molstruc.2018.04.012

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=186718&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Aganov Albert Vartanovich	ru_RU
dc.contributor.author	Galiullina Leysan Faritovna	ru_RU
dc.contributor.author	Klochkov Vladimir Vasilevich	ru_RU
dc.contributor.author	Latfullin Ildus Anvarovich	ru_RU
dc.contributor.author	Musabirova Guzel Salavatovna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles // BioNanoScience, V. 6, 2016.-P. 352-354.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=186718&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Fluvastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. It lowers the overall blood cholesterol level, which is responsible for coronary artery diseases. Conformational features of fluvastatin in water solution were determined. NMR experiments showed that fluvastatin form molecular complex with model cell membrane. It intercalates into membrane surface by its aromatic part. Intermolecular distances between dodecylphosphocholine micelles and fluvastatin nuclei were calculated.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Nuclear magnetic resonance	ru_RU
dc.subject	Fluvastatin	ru_RU
dc.subject	Micelles	ru_RU
dc.subject	Molecular complex	ru_RU
dc.title	NMR Study of Conformational Structure of Fluvastatin and Its Complex with Dodecylphosphocholine Micelles	ru_RU
dc.type	Articles in international journals and collections	ru_RU