KFU. Card publication. Interaction of different statins with model membranes by NMR data

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

INTERACTION OF DIFFERENT STATINS WITH MODEL MEMBRANES BY NMR DATA

Form of presentation

Articles in international journals and collections

Year of publication

2017

Authors, employees of KFU

Aganov Albert Vartanovich, author

Aganova Oksana Vartanovna, author

Galiullina Leysan Faritovna, author

Klochkov Vladimir Vasilevich, author

Latfullin Ildus Anvarovich, author

Authors, postgraduates KFU

Musabirova Guzel Salavatovna, postgraduate kfu

Bibliographic description in the original language

L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. Interaction of different statins with model membranes by NMR data // BBA Biomembranes, V. 1859 I. 3, 2017.-P. 259-300.

Annotation

Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins reduce the amount of lowdensity lipoprotein (LDL) cholesterol,which is known as awell-established risk factor for atherosclerosis. Despite the fact that statins have a common pharmacologic target essential to sterol biosynthesis, their efficacy, safety, and potential non-LDL actions vary significantly for different statins. There is a hypothesis that pharmacological features of statins depend on their location in cell membrane, but to the present day there is a lack of information in literature on interactions of statins with the surface of the cell membrane in liquid media. The results of NMR experiments showed that all studied statins form intermolecular complexes with models of cell membranes (dodecylphosphocholine micelles) in water solution. Locations of pravastatin, simvastatin, fluvastatin and cerivastatin on model membranes were established by NOESY NMR data.

Keywords

NMR, Molecular complex, Dodecylphosphocholine, Micelles, Statins

The name of the journal

Biochimica et Biophysica Acta - Biomembranes

URL

http://dx.doi.org/10.1016/j.bbamem.2016.12.006

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=186717&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Aganov Albert Vartanovich	ru_RU
dc.contributor.author	Aganova Oksana Vartanovna	ru_RU
dc.contributor.author	Galiullina Leysan Faritovna	ru_RU
dc.contributor.author	Klochkov Vladimir Vasilevich	ru_RU
dc.contributor.author	Latfullin Ildus Anvarovich	ru_RU
dc.contributor.author	Musabirova Guzel Salavatovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	L.F. Galiullina, O.V. Aganova, I.A. Latfullin, G.S. Musabirova, A.V. Aganov, V.V. Klochkov. Interaction of different statins with model membranes by NMR data // BBA Biomembranes, V. 1859 I. 3, 2017.-P. 259-300.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=186717&p_lang=2	ru_RU
dc.description.abstract	Biochimica et Biophysica Acta - Biomembranes	ru_RU
dc.description.abstract	Hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors or statins reduce the amount of lowdensity lipoprotein (LDL) cholesterol,which is known as awell-established risk factor for atherosclerosis. Despite the fact that statins have a common pharmacologic target essential to sterol biosynthesis, their efficacy, safety, and potential non-LDL actions vary significantly for different statins. There is a hypothesis that pharmacological features of statins depend on their location in cell membrane, but to the present day there is a lack of information in literature on interactions of statins with the surface of the cell membrane in liquid media. The results of NMR experiments showed that all studied statins form intermolecular complexes with models of cell membranes (dodecylphosphocholine micelles) in water solution. Locations of pravastatin, simvastatin, fluvastatin and cerivastatin on model membranes were established by NOESY NMR data.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	NMR	ru_RU
dc.subject	Molecular complex	ru_RU
dc.subject	Dodecylphosphocholine	ru_RU
dc.subject	Micelles	ru_RU
dc.subject	Statins	ru_RU
dc.title	Interaction of different statins with model membranes by NMR data	ru_RU
dc.type	Articles in international journals and collections	ru_RU