| Form of presentation | Articles in international journals and collections |
| Year of publication | 2017 |
|
Akhmetzyanova Elvira Ruslanovna, author
Galieva Luiza Ramilevna, author
Zakirova Elena Yurevna, author
Kostennikov Aleksandr Aleksandrovich, author
Mukhamedshina Yana Olegovna, author
Rizvanov Albert Anatolevich, author
|
|
Akhmetzyanova Elvira Ruslanovna, postgraduate kfu
|
| Bibliographic description in the original language |
Mukhamedshina, Y.O., Zakirova, E.Y., Galieva, L.R., Kostennikov, A.A.,
Akhmetzyanova, E.R. and Rizvanov, A.A., 2017. Distribution and survival of
transplanted adipose-derived mesenchymal stem cells in the spinal cord
injury. BioNanoScience, 7(4), pp.608-612. |
| Annotation |
Current expectations for successful treatment of
post-traumatic disorders in the CNS are associated with cellbased
technologies. Mesenchymal stem cells, which are under
intensive study, appear to be the most promising. At the same
time, mechanisms of their effect on post-traumatic regeneration
of the spinal cord and their behavior and migration properties in
neurodegenerative lesions are not investigated in full. In our
study, we investigated the survival, migration, and phenotypic
characteristics of a fibrin matrix enclosed in adipose-derived
mesenchymal stem cells (AD-MSCs) by implanting them in
an area of the spinal cord injury in a subacute period. We
showed that adipose-derived mesenchymal stem cells retain
their viability in the area of SCI for up to 60 days and migrate
rostrally and caudally for more than 5 mm. Phenotyping of ADMSCs
in the spinal cord injury area performed on the seventh
day post-transplantation shows that Thy-1, CD 73, and Stro-1
are expressed; however, no CD 4 |
| Keywords |
Adipose-derived mesenchymal stem cells . Spinal
cord injury . Migration |
| The name of the journal |
BioNanoScience
|
| URL |
DOI 10.1007/s12668-017-0440-0 |
| Please use this ID to quote from or refer to the card |
https://repository.kpfu.ru/eng/?p_id=186328&p_lang=2 |
Full metadata record  |
| Field DC |
Value |
Language |
| dc.contributor.author |
Akhmetzyanova Elvira Ruslanovna |
ru_RU |
| dc.contributor.author |
Galieva Luiza Ramilevna |
ru_RU |
| dc.contributor.author |
Zakirova Elena Yurevna |
ru_RU |
| dc.contributor.author |
Kostennikov Aleksandr Aleksandrovich |
ru_RU |
| dc.contributor.author |
Mukhamedshina Yana Olegovna |
ru_RU |
| dc.contributor.author |
Rizvanov Albert Anatolevich |
ru_RU |
| dc.contributor.author |
Akhmetzyanova Elvira Ruslanovna |
ru_RU |
| dc.date.accessioned |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.available |
2017-01-01T00:00:00Z |
ru_RU |
| dc.date.issued |
2017 |
ru_RU |
| dc.identifier.citation |
Mukhamedshina, Y.O., Zakirova, E.Y., Galieva, L.R., Kostennikov, A.A.,
Akhmetzyanova, E.R. and Rizvanov, A.A., 2017. Distribution and survival of
transplanted adipose-derived mesenchymal stem cells in the spinal cord
injury. BioNanoScience, 7(4), pp.608-612. |
ru_RU |
| dc.identifier.uri |
https://repository.kpfu.ru/eng/?p_id=186328&p_lang=2 |
ru_RU |
| dc.description.abstract |
BioNanoScience |
ru_RU |
| dc.description.abstract |
Current expectations for successful treatment of
post-traumatic disorders in the CNS are associated with cellbased
technologies. Mesenchymal stem cells, which are under
intensive study, appear to be the most promising. At the same
time, mechanisms of their effect on post-traumatic regeneration
of the spinal cord and their behavior and migration properties in
neurodegenerative lesions are not investigated in full. In our
study, we investigated the survival, migration, and phenotypic
characteristics of a fibrin matrix enclosed in adipose-derived
mesenchymal stem cells (AD-MSCs) by implanting them in
an area of the spinal cord injury in a subacute period. We
showed that adipose-derived mesenchymal stem cells retain
their viability in the area of SCI for up to 60 days and migrate
rostrally and caudally for more than 5 mm. Phenotyping of ADMSCs
in the spinal cord injury area performed on the seventh
day post-transplantation shows that Thy-1, CD 73, and Stro-1
are expressed; however, no CD 4 |
ru_RU |
| dc.language.iso |
ru |
ru_RU |
| dc.subject |
|
ru_RU |
| dc.title |
Distribution and survival of
transplanted adipose-derived mesenchymal stem cells in the spinal cord
injury |
ru_RU |
| dc.type |
Articles in international journals and collections |
ru_RU |
|
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