KFU. Card publication. Effect of curcumin and gliotoxin on rat liver myofibroblasts culture

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FEDERAL UNIVERSITY

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EFFECT OF CURCUMIN AND GLIOTOXIN ON RAT LIVER MYOFIBROBLASTS CULTURE

Form of presentation

Articles in international journals and collections

Year of publication

2018

Язык

английский

Authors, employees of KFU

Gomzikova Marina Olegovna, author

Gumerova Anisa Azatovna, author

Zhuravleva Margarita Nikolaevna, author

Kiyasov Andrey Pavlovich, author

Rizvanov Albert Anatolevich, author

Shafigullina Aygul Kasyymovna, author

Other authors

Miyanovich Olya , author

Authors, students KFU

Reshad Akbor Prottoy, author

Bibliographic description in the original language

Shafigullina, A. K. Effect of curcumin and gliotoxin on rat liver myofibroblasts culture / A.K. Shafigullina, O. Mijanovich, R.A. Prottoy, M.N. Zhuravleva, M.O. Gomzikova, A.A. Gumerova, A.A. Rizvanov, A.P. Kiyasov // BioNanoScience. - 2018. - Vol. 8. - R. 522-536.

Annotation

Since 1990s, when it was demonstrated by Hammel and others, that liver fibrosis is reversible, researchers and physicians actively search for new antifibrotic therapies. In recent years knowledge of liver fibrosis pathophysiology has greatly advanced and new cellular and molecular mechanisms were described. The cells that determine extracellular matrix components distribution are myofibroblasts, but their origin is diverse. They can be activated hepatic stellate cells (HSC), portal fibroblasts (PF) or circulating mesenchymal stem cells of bone marrow. Activation of HSC and PF and their fibrogenic potential is upregulated by transcription factor NF-ƙB. Among large number of substrates to inhibit NF-ƙB and induce apoptosis we chose curcumin and gliotoxin. Primarily in current work we optimized the explantation culture method for isolation of hepatic myofibroblasts and received two different cultures – myofibroblasts of HSC and PF origin. Exposition of 50 ?M curcumin and 0,1 ?M gliotoxin

Keywords

Hepatic stellate cells, portal fibroblasts, myofibroblasts, NF-ƙB, curcumin, gliotoxin, apoptosis, liver fibrosis

The name of the journal

BioNanoScience

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/131561/F_Shafigullina_et_al_2018_BioNanoScience.pdf?sequence=1&isAllowed=y

URL

https://link.springer.com/epdf/10.1007/s12668-017-0494-z?author_access_token=0oNtm7OnzacjCbYfkpkpz_e4RwlQNchNByi7wbcMAY7b52jFaQojlLqUe6CdhU_jBQ7pwKuCMDSU3FP2m1Xh9eq-I5zIxJAVP5PspPccwTHIIj-nf5bkn_UE7cnBBaCniSPz3GIzuuvdJw7aqx9Pig%3D%3D

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=181999&p_lang=2

Resource files

File name	Size (MB)	Format
F_Shafigullina_et_al_2018_BioNanoScience.pdf	2,72	pdf	show / download
F_skan_titulnika.jpg	0,08	jpg	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gomzikova Marina Olegovna	ru_RU
dc.contributor.author	Gumerova Anisa Azatovna	ru_RU
dc.contributor.author	Zhuravleva Margarita Nikolaevna	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Rizvanov Albert Anatolevich	ru_RU
dc.contributor.author	Shafigullina Aygul Kasyymovna	ru_RU
dc.contributor.author	Miyanovich Olya	ru_RU
dc.contributor.author	Reshad Akbor Prottoy	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Shafigullina, A. K. Effect of curcumin and gliotoxin on rat liver myofibroblasts culture / A.K. Shafigullina, O. Mijanovich, R.A. Prottoy, M.N. Zhuravleva, M.O. Gomzikova, A.A. Gumerova, A.A. Rizvanov, A.P. Kiyasov // BioNanoScience. - 2018. - Vol. 8. - Р. 522-536.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=181999&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Since 1990s, when it was demonstrated by Hammel and others, that liver fibrosis is reversible, researchers and physicians actively search for new antifibrotic therapies. In recent years knowledge of liver fibrosis pathophysiology has greatly advanced and new cellular and molecular mechanisms were described. The cells that determine extracellular matrix components distribution are myofibroblasts, but their origin is diverse. They can be activated hepatic stellate cells (HSC), portal fibroblasts (PF) or circulating mesenchymal stem cells of bone marrow. Activation of HSC and PF and their fibrogenic potential is upregulated by transcription factor NF-ƙB. Among large number of substrates to inhibit NF-ƙB and induce apoptosis we chose curcumin and gliotoxin. Primarily in current work we optimized the explantation culture method for isolation of hepatic myofibroblasts and received two different cultures – myofibroblasts of HSC and PF origin. Exposition of 50 ?M curcumin and 0,1 ?M gliotoxin	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hepatic stellate cells	ru_RU
dc.subject	portal fibroblasts	ru_RU
dc.subject	myofibroblasts	ru_RU
dc.subject	NF-ƙB	ru_RU
dc.subject	curcumin	ru_RU
dc.subject	gliotoxin	ru_RU
dc.subject	apoptosis	ru_RU
dc.subject	liver fibrosis	ru_RU
dc.title	Effect of curcumin and gliotoxin on rat liver myofibroblasts culture	ru_RU
dc.type	Articles in international journals and collections	ru_RU