KFU. Card publication. The influence of methoxamine on the isolated heart chronotropy and inotropy

KAZAN
FEDERAL UNIVERSITY

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THE INFLUENCE OF METHOXAMINE ON THE ISOLATED HEART CHRONOTROPY AND INOTROPY

Form of presentation

Articles in international journals and collections

Year of publication

2018

Язык

английский

Authors, employees of KFU

Zefirov Timur Lvovich, author

Ziyatdinova Nafisa Ilgizovna, author

Khabibrakhmanov Insaf Ilkhamovich, author

Other authors

Zefirova J. , author

Bibliographic description in the original language

Zefirov T.L. The influence of methoxamine on the isolated heart chronotropy and inotropy / T.L. Zefirov, I.I. Khabibrakhmanov, J.T. Zefirova, N.I. Ziyatdinova // European Journal of Clinical Investigation. -2018. - Vol. 48, S.1. -P. 139.

Annotation

The stimulation of α1-ARs with MX induced bradycardia in isolated heart. Still in our experiments all studied concentrations of methoxamine induced negative inotropic reaction of isolated left ventricle of rats. The intensity of the negative inotropic effect depended on concentration of the agonist. Decreased heart rate and myocardium contractility with activation of α1-AR may be secondary to decreased ICa due activation of protein kinase C. It?s quite possible that α1-AR participate in more delicate regulation of cardiac function and most likely effects of stimulation depend on activity of other receptors and different intracellular systems.

Keywords

Rat, heart, alpha1-adrenoceptors, metoxamine.

The name of the journal

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

URL

https://onlinelibrary.wiley.com/toc/13652362/2018/48/S1

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=181926&p_lang=2

Resource files

File name	Size (MB)	Format
Vliyanie_MH_na_hrono__i_inotropiju_izol_serdca_2222.pdf	1,14	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Ziyatdinova Nafisa Ilgizovna	ru_RU
dc.contributor.author	Khabibrakhmanov Insaf Ilkhamovich	ru_RU
dc.contributor.author	Zefirova J.	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Zefirov T.L. The influence of methoxamine on the isolated heart chronotropy and inotropy / T.L. Zefirov, I.I. Khabibrakhmanov, J.T. Zefirova, N.I. Ziyatdinova // European Journal of Clinical Investigation. -2018. - Vol. 48, S.1. -P. 139.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=181926&p_lang=2	ru_RU
dc.description.abstract	EUROPEAN JOURNAL OF CLINICAL INVESTIGATION	ru_RU
dc.description.abstract	The stimulation of α1-ARs with MX induced bradycardia in isolated heart. Still in our experiments all studied concentrations of methoxamine induced negative inotropic reaction of isolated left ventricle of rats. The intensity of the negative inotropic effect depended on concentration of the agonist. Decreased heart rate and myocardium contractility with activation of α1-AR may be secondary to decreased ICa due activation of protein kinase C. It?s quite possible that α1-AR participate in more delicate regulation of cardiac function and most likely effects of stimulation depend on activity of other receptors and different intracellular systems.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Rat	ru_RU
dc.subject	heart	ru_RU
dc.subject	alpha1-adrenoceptors	ru_RU
dc.subject	metoxamine.	ru_RU
dc.title	The influence of methoxamine on the isolated heart chronotropy and inotropy	ru_RU
dc.type	Articles in international journals and collections	ru_RU