KFU. Card publication. Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia

KAZAN
FEDERAL UNIVERSITY

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NETWORK-DRIVEN ACTIVITY AND NEURONAL EXCITABILITY IN HIPPOCAMPUS OF NEONATAL RATS WITH PRENATAL HYPERHOMOCYSTEINEMIA

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Zakharov Andrey Viktorovich, author

Kurmashova Evgeniya Denisovna, author

Yakovlev Aleksey Valerevich, author

Bibliographic description in the original language

Yakovlev A.V. Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia/ Yakovlev AV, Kurmashova E, Zakharov A., Sitdikova GF // BioNanoScience March 2018, Volume 8, Issue 1, pp 304–309

Annotation

Maternal hyperhomocysteinemia (HHCy) correlated with a number of complications such as abruption placentae, preeclampsia syndrome, in utero fetal death and fetal neural tube defects, cognitive impairment, and neurodegeneration during postnatal development. In the present study, we investigated the effects of prenatal HHCy on electrophysiological features and spontaneous network activity of neurons in hippocampus of rats of the first postnatal week. The analysis of intrinsic electrophysiological properties of pyramidal neurons has shown the decrease of the membrane capacitance and the threshold of generation of action potentials in rats with prenatal HHCy without alteration of the input resistance and resting membrane potential. In trains of action potentials elicited with prolonged current injections, an increase of interspike intervals and a broadening of action potentials during repetitive firing were observed in control neurons. In the neurons of pups with prenatal HHCy, the changes

Keywords

Maternal hyperhomocysteinemia Hippocampus Giant depolarizing potentials Neuronal excitability

The name of the journal

BioNanoScience

URL

https://link.springer.com/article/10.1007/s12668-017-0450-y

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=178323&p_lang=2

Resource files

File name	Size (MB)	Format
10.1007%2Fs12668_017_0450_y.pdf	0,51	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Zakharov Andrey Viktorovich	ru_RU
dc.contributor.author	Kurmashova Evgeniya Denisovna	ru_RU
dc.contributor.author	Yakovlev Aleksey Valerevich	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Yakovlev A.V. Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia/ Yakovlev AV, Kurmashova E, Zakharov A., Sitdikova GF // BioNanoScience March 2018, Volume 8, Issue 1, pp 304–309	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=178323&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Maternal hyperhomocysteinemia (HHCy) correlated with a number of complications such as abruption placentae, preeclampsia syndrome, in utero fetal death and fetal neural tube defects, cognitive impairment, and neurodegeneration during postnatal development. In the present study, we investigated the effects of prenatal HHCy on electrophysiological features and spontaneous network activity of neurons in hippocampus of rats of the first postnatal week. The analysis of intrinsic electrophysiological properties of pyramidal neurons has shown the decrease of the membrane capacitance and the threshold of generation of action potentials in rats with prenatal HHCy without alteration of the input resistance and resting membrane potential. In trains of action potentials elicited with prolonged current injections, an increase of interspike intervals and a broadening of action potentials during repetitive firing were observed in control neurons. In the neurons of pups with prenatal HHCy, the changes	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Network-Driven Activity and Neuronal Excitability in Hippocampus of Neonatal Rats with Prenatal Hyperhomocysteinemia	ru_RU
dc.type	Articles in international journals and collections	ru_RU