Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
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ANTIMICROBIAL EFFECTS OF SULFONYL DERIVATIVE OF 2 (5H)-FURANONE AGAINST PLANKTONIC AND BIOFILM ASSOCIATED METHICILLIN-RESISTANT AND-SUSCEPTIBLE STAPHYLOCOCCUS AUREUS
Form of presentationArticles in international journals and collections
Year of publication2017
Языканглийский
  • Baydamshina Diana Rafisovna, author
  • Bogachev Mikhail Igorevich, author
  • Kayumov Ayrat Rashitovich, author
  • Kurbangalieva Almira Rafaelovna, author
  • Latypova Liliya Zinnurovna, author
  • Rozhina Elvira Vyacheslavovna, author
  • Trizna Elena Yurevna, author
  • Fakhrullin Ravil Faridovich, author
  • Sharafutdinov Irshad Sultanovich, author
  • Klinger-Strobel Mareike , author
  • Makarewicz Oliwia , author
  • Pletz Mathias W. , author
  • Bibliographic description in the original language Sharafutdinov I.S. Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus / I.S. Sharafutdinov, E.Y. Trizna, D.R. Baidamshina, M.N. Ryzhikova, R.R. Sibgatullina, A.M. Khabibrakhmanova, L.Z. Latypova, A.R. Kurbangalieva, E.V. Rozhina, M. Klinger-Strobel, R.F. Fakhrullin, M.W. Pletz, M.I. Bogachev, A.R. Kayumov, O. Makarewicz // Frontiers in microbiology. - 2017. - V.8. - P.2246.
    Annotation The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety. Minimal inhibitory and bactericidal concentration values (MIC and MBC) of F105 were 10 and 40 mg/L, respectively, suggesting F105 biocidal properties. F105 exhibits pronounced activity against biofilm-embedded S. aureus and increases the efficacy of aminoglycosides (amikacin, gentamicin, and kanamycin) and benzalkonium chloride with fractional inhibitory concentration index valu
    Keywords 2(5H)-furanones, sulfones, Staphylococcus aureus, MRSA, biofilm, antimicrobials synergism
    The name of the journal Frontiers in Microbiology
    URL https://www.frontiersin.org/articles/10.3389/fmicb.2017.02246/full
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=174516&p_lang=2

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