KFU. Card publication. Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus

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ANTIMICROBIAL EFFECTS OF SULFONYL DERIVATIVE OF 2 (5H)-FURANONE AGAINST PLANKTONIC AND BIOFILM ASSOCIATED METHICILLIN-RESISTANT AND-SUSCEPTIBLE STAPHYLOCOCCUS AUREUS

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Baydamshina Diana Rafisovna, author

Bogachev Mikhail Igorevich, author

Kayumov Ayrat Rashitovich, author

Kurbangalieva Almira Rafaelovna, author

Latypova Liliya Zinnurovna, author

Rozhina Elvira Vyacheslavovna, author

Trizna Elena Yurevna, author

Fakhrullin Ravil Faridovich, author

Sharafutdinov Irshad Sultanovich, author

Other authors

Klinger-Strobel Mareike , author

Makarewicz Oliwia , author

Pletz Mathias W. , author

Bibliographic description in the original language

Sharafutdinov I.S. Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus / I.S. Sharafutdinov, E.Y. Trizna, D.R. Baidamshina, M.N. Ryzhikova, R.R. Sibgatullina, A.M. Khabibrakhmanova, L.Z. Latypova, A.R. Kurbangalieva, E.V. Rozhina, M. Klinger-Strobel, R.F. Fakhrullin, M.W. Pletz, M.I. Bogachev, A.R. Kayumov, O. Makarewicz // Frontiers in microbiology. - 2017. - V.8. - P.2246.

Annotation

The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety. Minimal inhibitory and bactericidal concentration values (MIC and MBC) of F105 were 10 and 40 mg/L, respectively, suggesting F105 biocidal properties. F105 exhibits pronounced activity against biofilm-embedded S. aureus and increases the efficacy of aminoglycosides (amikacin, gentamicin, and kanamycin) and benzalkonium chloride with fractional inhibitory concentration index valu

Keywords

2(5H)-furanones, sulfones, Staphylococcus aureus, MRSA, biofilm, antimicrobials synergism

The name of the journal

Frontiers in Microbiology

URL

https://www.frontiersin.org/articles/10.3389/fmicb.2017.02246/full

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=174516&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Baydamshina Diana Rafisovna	ru_RU
dc.contributor.author	Bogachev Mikhail Igorevich	ru_RU
dc.contributor.author	Kayumov Ayrat Rashitovich	ru_RU
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Latypova Liliya Zinnurovna	ru_RU
dc.contributor.author	Rozhina Elvira Vyacheslavovna	ru_RU
dc.contributor.author	Trizna Elena Yurevna	ru_RU
dc.contributor.author	Fakhrullin Ravil Faridovich	ru_RU
dc.contributor.author	Sharafutdinov Irshad Sultanovich	ru_RU
dc.contributor.author	Klinger-Strobel Mareike	ru_RU
dc.contributor.author	Makarewicz Oliwia	ru_RU
dc.contributor.author	Pletz Mathias W.	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Sharafutdinov I.S. Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus / I.S. Sharafutdinov, E.Y. Trizna, D.R. Baidamshina, M.N. Ryzhikova, R.R. Sibgatullina, A.M. Khabibrakhmanova, L.Z. Latypova, A.R. Kurbangalieva, E.V. Rozhina, M. Klinger-Strobel, R.F. Fakhrullin, M.W. Pletz, M.I. Bogachev, A.R. Kayumov, O. Makarewicz // Frontiers in microbiology. - 2017. - V.8. - P.2246.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=174516&p_lang=2	ru_RU
dc.description.abstract	Frontiers in Microbiology	ru_RU
dc.description.abstract	The gram-positive opportunistic bacterium Staphylococcus aureus is one of the most common causatives of a variety of diseases including skin and skin structure infection or nosocomial catheter-associated infections. The biofilm formation that is an important virulence factor of this microorganism renders the antibiotic therapy ineffective, because biofilm-embedded bacteria exhibit strongly increased tolerance to antimicrobials. Here, we describe a novel 3-chloro-5(S)-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4-[4-methylphenylsulfonyl]-2(5H)-furanone (F105), possessing a sulfonyl group and l-menthol moiety. Minimal inhibitory and bactericidal concentration values (MIC and MBC) of F105 were 10 and 40 mg/L, respectively, suggesting F105 biocidal properties. F105 exhibits pronounced activity against biofilm-embedded S. aureus and increases the efficacy of aminoglycosides (amikacin, gentamicin, and kanamycin) and benzalkonium chloride with fractional inhibitory concentration index valu	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	2(5H)-furanones	ru_RU
dc.subject	sulfones	ru_RU
dc.subject	Staphylococcus aureus	ru_RU
dc.subject	MRSA	ru_RU
dc.subject	biofilm	ru_RU
dc.subject	antimicrobials synergism	ru_RU
dc.title	Antimicrobial Effects of Sulfonyl Derivative of 2 (5H)-Furanone against Planktonic and Biofilm Associated Methicillin-Resistant and-Susceptible Staphylococcus aureus	ru_RU
dc.type	Articles in international journals and collections	ru_RU