KFU. Card publication. The competitive nature of STAT complex formation drives phenotype switching of T cells

KAZAN
FEDERAL UNIVERSITY

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THE COMPETITIVE NATURE OF STAT COMPLEX FORMATION DRIVES PHENOTYPE SWITCHING OF T CELLS

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Kotov Nikolay Viktorovich, author

Salakhieva Diana Vitalevna, author

Other authors

I. I Sadreev , Michael Z, Q Chen , Yoshinori Umezawa , Claudia Kemper, Gavin I Welsh Ildar I, author

Bibliographic description in the original language

Ildar I Sadreev, The competitive nature of STAT complex formation drives phenotype switching of T cells /Ildar I Sadreev, Michael Z Q Chen, Yoshinori Umezawa, Vadim N Biktashev, Claudia Kemper, Diana V Salakhieva, Gavin I Welsh, Nikolay V Kotov.-2017.-Cite as: arXiv:1701.05503 [q-bio.MN]

Annotation

Signal transducers and activators of transcription (STATs) are key molecular determinants of T cell fate and effector function. A number of inflammatory diseases are characterized by an altered balance of T cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms of how the same STAT proteins regulate both the development of different T cell phenotypes and their plasticity during changes in extracellular conditions remain unclear. In this study, we investigated the STAT mediated regulation of T cell phenotype formation and plasticity using mathematical modeling and experimental data for intracellular STAT signaling proteins. The close fit of our model predictions to the experimental data for IFN-{\gamma} to IL-10 switching allows us to propose a potential mechanism for T cell switching that regulates human Th1/Tr1 responses. According to this mechanism, T cell phenotype switching is due to

Keywords

Quantitative Biology, Molecular Networks

The name of the journal

IMMUNOLOGY

URL

https://arxiv.org/abs/1701.05503

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=170473&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kotov Nikolay Viktorovich	ru_RU
dc.contributor.author	Salakhieva Diana Vitalevna	ru_RU
dc.contributor.author	I. I Sadreev , Michael Z, Q Chen , Yoshinori Umezawa , Claudia Kemper, Gavin I Welsh Ildar I	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Ildar I Sadreev, The competitive nature of STAT complex formation drives phenotype switching of T cells /Ildar I Sadreev, Michael Z Q Chen, Yoshinori Umezawa, Vadim N Biktashev, Claudia Kemper, Diana V Salakhieva, Gavin I Welsh, Nikolay V Kotov.-2017.-Cite as: arXiv:1701.05503 [q-bio.MN]	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=170473&p_lang=2	ru_RU
dc.description.abstract	IMMUNOLOGY	ru_RU
dc.description.abstract	Signal transducers and activators of transcription (STATs) are key molecular determinants of T cell fate and effector function. A number of inflammatory diseases are characterized by an altered balance of T cell phenotypes and cytokine secretion. STATs, therefore, represent viable therapeutic targets in numerous pathologies. However, the underlying mechanisms of how the same STAT proteins regulate both the development of different T cell phenotypes and their plasticity during changes in extracellular conditions remain unclear. In this study, we investigated the STAT mediated regulation of T cell phenotype formation and plasticity using mathematical modeling and experimental data for intracellular STAT signaling proteins. The close fit of our model predictions to the experimental data for IFN-{\gamma} to IL-10 switching allows us to propose a potential mechanism for T cell switching that regulates human Th1/Tr1 responses. According to this mechanism, T cell phenotype switching is due to	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Quantitative Biology	ru_RU
dc.subject	Molecular Networks	ru_RU
dc.title	The competitive nature of STAT complex formation drives phenotype switching of T cells	ru_RU
dc.type	Articles in international journals and collections	ru_RU