KFU. Card publication. The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster

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THE ACTION OF MONOTERPENOIDS WITH PROMISING ANTIPARKINSONIAN ACTIVITY ON FERTILITY OF DROSOPHILA MELANOGASTER

Form of presentation

Articles in Russian journals and collections

Year of publication

2017

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Authors, employees of KFU

Khamidullina Raisa Gusmanovna, author

Bibliographic description in the original language

Maxim V. TRUSHIN, Raisa G. KHAMIDULLINA,Oleg V. ARDASHOV,Konstantin P. VOLCHO2,Nariman F. SALAKHUTDINOV. The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster // Marmara Pharmaceutical Journal 21/4: 987-991, 2017. DOI: 10.12991/mpj.2017.29

Annotation

Adequate treatment of Parkinson's disease is an important medical issue. Patients are suffered from numerous side effects of the widely used drugs. It has been found recently that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol and its diacetate demonstrate high antiparkinsonian activity in some animal models. At the same time, their genetic safety was not studied yet. The aim of this research was to investigate the effect of these compounds with antiparkinsonian activities on reproduction of D. melanogaster. Over 4000 of fruitflies cultivated under the action of these compounds were analyzed. It was found that the chemicals did not provoke genetic mutations or alter reproduction of D. melanogaster. The possible explanations for the detected phenomena are provided. It was found that the compounds do not affect fertility in Drosophila..

Keywords

Parkinson?s disease; fertility; drosophila; (1R,2R,6S)- 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol; acetate;

The name of the journal

Marmara Pharmaceutical Journal

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=168457&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Khamidullina Raisa Gusmanovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Maxim V. TRUSHIN, Raisa G. KHAMIDULLINA,Oleg V. ARDASHOV,Konstantin P. VOLCHO2,Nariman F. SALAKHUTDINOV. The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster // Marmara Pharmaceutical Journal 21/4: 987-991, 2017. DOI: 10.12991/mpj.2017.29	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=168457&p_lang=2	ru_RU
dc.description.abstract	Marmara Pharmaceutical Journal	ru_RU
dc.description.abstract	Adequate treatment of Parkinson's disease is an important medical issue. Patients are suffered from numerous side effects of the widely used drugs. It has been found recently that monoterpenoid (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl) cyclohex-3-ene-1,2-diol and its diacetate demonstrate high antiparkinsonian activity in some animal models. At the same time, their genetic safety was not studied yet. The aim of this research was to investigate the effect of these compounds with antiparkinsonian activities on reproduction of D. melanogaster. Over 4000 of fruitflies cultivated under the action of these compounds were analyzed. It was found that the chemicals did not provoke genetic mutations or alter reproduction of D. melanogaster. The possible explanations for the detected phenomena are provided. It was found that the compounds do not affect fertility in Drosophila..	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Parkinson?s disease; fertility; drosophila; (1R	ru_RU
dc.subject	2R	ru_RU
dc.subject	6S)- 3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1	ru_RU
dc.subject	2-diol; acetate;	ru_RU
dc.title	The action of monoterpenoids with promising antiparkinsonian activity on fertility of Drosophila melanogaster	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU