KFU. Card publication. Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa

KAZAN
FEDERAL UNIVERSITY

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NOVEL DRUG TARGETS IN CELL WALL BIOSYNTHESIS EXPLOITED BY GENE DISRUPTION IN PSEUDOMONAS AERUGINOSA

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Shuralev Eduard Arkadevich, author

Other authors

Braun Yvonne , author

Elamin Ayssar A. , author

Huck Carmen , author

Maringer Marko , author

Oehlmann Wulf , author

Rohde Manfred , author

Singh Mahavir , author

Steinicke Susanne , author

Wanas Hanaa , author

Bibliographic description in the original language

Elamin A.A. Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa / A.A. Elamin, S. Steinicke, W. Oehlmann, Y. Braun, H. Wanas, E.A. Shuralev, C. Huck, M. Maringer, M. Rohde, M. Singh // PLoS ONE. - 2017. - 12(10): e0186801. DOI: 10.1371/journal.pone.0186801. WOS:000413168100091

Annotation

This study demonstrates that cell wall targets contribute significantly to intracellular survival, in vivo growth, and pathogenesis of P. aeruginosa. In conclusion, these findings establish a link between cell wall targets and virulence of P. aeruginosa and thus may lead to development of novel drugs for the treatment of P. aeruginosa infection.

Keywords

ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE, BACTERIAL BIOFILM FORMATION, UDP-N-ACETYLGLUCOSAMINE, ESCHERICHIA-COLI, VIRULENCE FACTORS; LIPOPOLYSACCHARIDE BIOSYNTHESIS; OPPORTUNISTIC PATHOGEN, CRYSTAL-STRUCTURE, ENDOTOXINS, ANTIBIOTICS

The name of the journal

PLos ONE

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/117107/F_Shuralev_Pseudomona.pdf?sequence=1&isAllowed=y

URL

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186801

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=167144&p_lang=2

Resource files

File name	Size (MB)	Format
F_Shuralev_Pseudomona.pdf	17,55	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Shuralev Eduard Arkadevich	ru_RU
dc.contributor.author	Braun Yvonne	ru_RU
dc.contributor.author	Elamin Ayssar A.	ru_RU
dc.contributor.author	Huck Carmen	ru_RU
dc.contributor.author	Maringer Marko	ru_RU
dc.contributor.author	Oehlmann Wulf	ru_RU
dc.contributor.author	Rohde Manfred	ru_RU
dc.contributor.author	Singh Mahavir	ru_RU
dc.contributor.author	Steinicke Susanne	ru_RU
dc.contributor.author	Wanas Hanaa	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Elamin A.A. Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa / A.A. Elamin, S. Steinicke, W. Oehlmann, Y. Braun, H. Wanas, E.A. Shuralev, C. Huck, M. Maringer, M. Rohde, M. Singh // PLoS ONE. - 2017. - 12(10): e0186801. DOI: 10.1371/journal.pone.0186801. WOS:000413168100091	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=167144&p_lang=2	ru_RU
dc.description.abstract	PLos ONE	ru_RU
dc.description.abstract	This study demonstrates that cell wall targets contribute significantly to intracellular survival, in vivo growth, and pathogenesis of P. aeruginosa. In conclusion, these findings establish a link between cell wall targets and virulence of P. aeruginosa and thus may lead to development of novel drugs for the treatment of P. aeruginosa infection.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	ACETYLGLUCOSAMINE ENOLPYRUVYL TRANSFERASE	ru_RU
dc.subject	BACTERIAL BIOFILM FORMATION	ru_RU
dc.subject	UDP-N-ACETYLGLUCOSAMINE	ru_RU
dc.subject	ESCHERICHIA-COLI	ru_RU
dc.subject	VIRULENCE FACTORS; LIPOPOLYSACCHARIDE BIOSYNTHESIS; OPPORTUNISTIC PATHOGEN	ru_RU
dc.subject	CRYSTAL-STRUCTURE	ru_RU
dc.subject	ENDOTOXINS	ru_RU
dc.subject	ANTIBIOTICS	ru_RU
dc.title	Novel drug targets in cell wall biosynthesis exploited by gene disruption in Pseudomonas aeruginosa	ru_RU
dc.type	Articles in international journals and collections	ru_RU