KFU. Card publication. Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

INTERACTION OF POLYACRYLIC ACID WITH LIPID BILAYERS: EFFECT OF POLYMER MASS

Form of presentation

Articles in international journals and collections

Year of publication

2013

Язык

английский

Authors, employees of KFU

Gnezdilov Oleg Ivanovich, author

Filippov Andrey Vasilevich, author

Bibliographic description in the original language

Munavirov B, Gnezdilov O, Rudakova M, Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass//Magnetic Resonance in Chemistry. - 2013. - Vol.51, Is.11. - P.750-755.

Annotation

Polyanion-coated lipid vesicles are proposed to have an appreciable potential for drug delivery because of their ability to control the permeability of lipid bilayers by environmental parameters such as pH and temperature. However, details of the interaction of this class of polymers with lipids and theirmechanisms of induced permeability are still being debated. In thiswork,we applied 1H NOESY to study details of the interaction of polyacrylic acid (PAA) fractions of molecular weights 5 and 240 kDa with dimyristoylphosphatidylcholine vesicles.We showed that PAA of two differentmolecularmassesmodifies lipid bilayers increasing disorder and probability of close contact between polar and hydrophobic groups. PAA molecules adsorb near the interface of lipid bilayers but do not penetrate into the hydrophobic core of the bilayer and, thus, cannot participate in formation of transbilayer channels, proposed in earlier works.

Keywords

Interaction, polyacrylic acid, lipid bilayers, polymer mass, NMR

The name of the journal

Magnetic Resonance in Chemistry

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885130275&partnerID=40&md5=848dd2bb59023b023c22ee5bc3cdf0d0

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=162912&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gnezdilov Oleg Ivanovich	ru_RU
dc.contributor.author	Filippov Andrey Vasilevich	ru_RU
dc.date.accessioned	2013-01-01T00:00:00Z	ru_RU
dc.date.available	2013-01-01T00:00:00Z	ru_RU
dc.date.issued	2013	ru_RU
dc.identifier.citation	Munavirov B, Gnezdilov O, Rudakova M, Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass//Magnetic Resonance in Chemistry. - 2013. - Vol.51, Is.11. - P.750-755.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=162912&p_lang=2	ru_RU
dc.description.abstract	Magnetic Resonance in Chemistry	ru_RU
dc.description.abstract	Polyanion-coated lipid vesicles are proposed to have an appreciable potential for drug delivery because of their ability to control the permeability of lipid bilayers by environmental parameters such as pH and temperature. However, details of the interaction of this class of polymers with lipids and theirmechanisms of induced permeability are still being debated. In thiswork,we applied 1H NOESY to study details of the interaction of polyacrylic acid (PAA) fractions of molecular weights 5 and 240 kDa with dimyristoylphosphatidylcholine vesicles.We showed that PAA of two differentmolecularmassesmodifies lipid bilayers increasing disorder and probability of close contact between polar and hydrophobic groups. PAA molecules adsorb near the interface of lipid bilayers but do not penetrate into the hydrophobic core of the bilayer and, thus, cannot participate in formation of transbilayer channels, proposed in earlier works.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Interaction	ru_RU
dc.subject	polyacrylic acid	ru_RU
dc.subject	lipid bilayers	ru_RU
dc.subject	polymer mass	ru_RU
dc.subject	NMR	ru_RU
dc.title	Interaction of polyacrylic acid with lipid bilayers: Effect of polymer mass	ru_RU
dc.type	Articles in international journals and collections	ru_RU