KFU. Card publication. Target cells for stem cell factor in the adult islets of Langerhans, simultaneously synthesizing glucagon and insulin

KAZAN
FEDERAL UNIVERSITY

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TARGET CELLS FOR STEM CELL FACTOR IN THE ADULT ISLETS OF LANGERHANS, SIMULTANEOUSLY SYNTHESIZING GLUCAGON AND INSULIN

Form of presentation

Articles in international journals and collections

Year of publication

2018

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Authors, employees of KFU

Andreeva Dina Ivanovna, author

Gumerova Anisa Azatovna, author

Kiyasov Andrey Pavlovich, author

Titova Angelina Andreevna, author

Titova Marina Aleksandrovna, author

Bibliographic description in the original language

Kaligin M. Target Cells for Stem Cell Factor in the Adult Islets of Langerhans, Simultaneously Synthesizing Glucagon and Insulin / Kaligin M., Andreeva D., Titova A., Titova M., Gumerova A., Kiyasov A. // BioNanoScience. -2018. - Vol.8, Is.1. - P.296-298. DOI 10.1007/s12668-017-0444-9

Annotation

C-kit—a stem cell receptor, or CD117, is one of the markers of human pancreatic endocrinocyte progenitor cells. Its important role in the proliferation and differentiation of pancreatic endocrine cells during human prenatal development has already been proven. However, the presence and role of c-kit-positive cells in adult pancreatic islets remains unclear. The purpose of our study was to establish the presence of c-kit-positive cells in the adult pancreatic islets and to assess whether they retain the ability to proliferate during a lifetime. We studied pancreatic autopsies of adults aged 50 to 70 years, which were obtained in pathology departments of Kazan hospitals. Samples of the pancreas were embedded in paraffin using standard techniques. Paraffin sections of the pancreas were stained immunohistochemically with commercial antibodies against c-kit, insulin, glucagon, and Ki-67. Few c-kit-positive cells simultaneously secreting insulin or glucagon were detected in all samples studi

Keywords

C-kit , CD117, adult pancreatic islets, pancreatic progenitor cells

The name of the journal

BioNanoScience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=162344&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Andreeva Dina Ivanovna	ru_RU
dc.contributor.author	Gumerova Anisa Azatovna	ru_RU
dc.contributor.author	Kiyasov Andrey Pavlovich	ru_RU
dc.contributor.author	Titova Angelina Andreevna	ru_RU
dc.contributor.author	Titova Marina Aleksandrovna	ru_RU
dc.date.accessioned	2018-01-01T00:00:00Z	ru_RU
dc.date.available	2018-01-01T00:00:00Z	ru_RU
dc.date.issued	2018	ru_RU
dc.identifier.citation	Kaligin M. Target Cells for Stem Cell Factor in the Adult Islets of Langerhans, Simultaneously Synthesizing Glucagon and Insulin / Kaligin M., Andreeva D., Titova A., Titova M., Gumerova A., Kiyasov A. // BioNanoScience. -2018. - Vol.8, Is.1. - P.296-298. DOI 10.1007/s12668-017-0444-9	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=162344&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	C-kit—a stem cell receptor, or CD117, is one of the markers of human pancreatic endocrinocyte progenitor cells. Its important role in the proliferation and differentiation of pancreatic endocrine cells during human prenatal development has already been proven. However, the presence and role of c-kit-positive cells in adult pancreatic islets remains unclear. The purpose of our study was to establish the presence of c-kit-positive cells in the adult pancreatic islets and to assess whether they retain the ability to proliferate during a lifetime. We studied pancreatic autopsies of adults aged 50 to 70 years, which were obtained in pathology departments of Kazan hospitals. Samples of the pancreas were embedded in paraffin using standard techniques. Paraffin sections of the pancreas were stained immunohistochemically with commercial antibodies against c-kit, insulin, glucagon, and Ki-67. Few c-kit-positive cells simultaneously secreting insulin or glucagon were detected in all samples studi	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	C-kit	ru_RU
dc.subject	CD117	ru_RU
dc.subject	adult pancreatic islets	ru_RU
dc.subject	pancreatic progenitor cells	ru_RU
dc.title	Target cells for stem cell factor in the adult islets of Langerhans, simultaneously synthesizing glucagon and insulin	ru_RU
dc.type	Articles in international journals and collections	ru_RU