KFU. Card publication. Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential

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FEDERAL UNIVERSITY

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SALT STRESS INDUCED BIOSYNTHESIS OF BINASE II, THE SECOND BACILLUS PUMILUS 7P RIBONUCLEASE WITH THERAPEUTIC POTENTIAL

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Ilinskaya Olga Nikolaevna, author

Kolpakov Aleksey Ivanovich, author

Kharitonova Mayya Aleksandrovna, author

Bibliographic description in the original language

Kharitonova M.A. Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential /Kharitonova M.A. , A.I.Kolpakov., O.N. //BioNanoScience. -2017. -V.7, (1). –P. 148-150.

Annotation

BioNanoSciens

Keywords

Bacillus pumilus, biosynthesis activation, ribonuclease, binase II Salt stress

The name of the journal

BioNanoSciens

URL

https://www.scopus.com/record/display.uri?eid=2-s2.0-85017658444&origin=resultslist&sort=plf-f&src=s&sid=48A7A765AA641A55C655397B6203AA62.wsnAw8kcdt7IPYLO0V48gA%3a20&sot=autdocs&sdt=autdocs&sl=17&s=AU-ID%287005874875%29&relpos=0&citeCnt=0&searchTerm=

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=160777&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ilinskaya Olga Nikolaevna	ru_RU
dc.contributor.author	Kolpakov Aleksey Ivanovich	ru_RU
dc.contributor.author	Kharitonova Mayya Aleksandrovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Kharitonova M.A. Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential /�haritonova �.�. , �.I.Kolpakov., O.N. //BioNanoScience. -2017. -V.7, (1). –P. 148-150.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=160777&p_lang=2	ru_RU
dc.description.abstract	BioNanoSciens	ru_RU
dc.description.abstract	Besides the dominant well-studied low-molecular weight ribonuclease (RNase) binase I, Bacillus pumilus secretes a high-molecular weight binase II which differs from binase I by the absence of substrate specificity and the mode of RNA cleavage. Similar to many other RNases, binase II was proposed to have therapeutic potential. Deciphering molecular mechanisms of binase II biosynthesis regulation is required to boost expression of this RNase. Here, we have shown that increase of salinity in growth medium leads to elevated biosynthesis level of binase II. We detected in the binase II promoter the gene sequences homologous to the recognition sites of response regulator DegU. DegS-DegU signal transduction system is stimulated by high salt concentrations. Using the Bacillus subtilis strains with various mutations in DegU gene, we have shown that the DegS-DegU system is responsible for the increase of binase II gene expression under salt stress, indeed	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Bacillus pumilus	ru_RU
dc.subject	biosynthesis activation	ru_RU
dc.subject	ribonuclease	ru_RU
dc.subject	binase II Salt stress	ru_RU
dc.title	Salt stress induced biosynthesis of binase ii, the second Bacillus pumilus 7p ribonuclease with therapeutic potential	ru_RU
dc.type	Articles in international journals and collections	ru_RU