KFU. Card publication. Unexpected activity of multiple targeted cancer drugs in regulating ciliary dynamics

KAZAN
FEDERAL UNIVERSITY

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- 中文
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UNEXPECTED ACTIVITY OF MULTIPLE TARGETED CANCER DRUGS IN REGULATING CILIARY DYNAMICS

Form of presentation

Conference proceedings in international journals and collections

Year of publication

2017

Authors, employees of KFU

Kiseleva Anna Alekseevna, author

Authors, postgraduates KFU

Kiseleva Anna Alekseevna, postgraduate kfu

Bibliographic description in the original language

The primary cilium is an antenna-like structure protruding from the cell surface, which provides a platform for receptors for signaling systems including PDGF-alpha, Hedgehog, Wnt, and others that influence cell differentiation and proliferation decisions. Under normal physiological growth conditions, the cilium forms after mitosis and in quiescent cells, extending from a basal body centered at a centriole, with timed resorption in G0 or early G1. Cancer cells have altered ciliary dynamics, with some (medulloblastomas and basal cell carcinomas) often dependent on cilia, and other tumor types downregulating them. In prior work, we defıned Aurora-A, an oncogenic kinase typically thought of as a mitotic regulator, as transiently activated at the basal body, and absolutely required for resorption of cilia at the G0/G1 boundary, and we showed the targeted Aurora-A inhibitor entirely blocked ciliary resorption. In subsequent work, we found that a second drug, the EGFR inhibitor erlotinib, al

Keywords

primary cilium, ALisertib, Sunitinib

Place of publication

Washington DC

Publishing house

AACR

URL

http://www.aacr.org/Meetings/Pages/MeetingDetail.aspx?EventItemID=105&DetailItemID=539&utm_source=social&utm_medium=twitter&utm_content=am17&utm_campaign=annual-meeting#.WU-7Amg19PY

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=160420&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Kiseleva Anna Alekseevna	ru_RU
dc.contributor.author	Kiseleva Anna Alekseevna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	The primary cilium is an antenna-like structure protruding from the cell surface, which provides a platform for receptors for signaling systems including PDGF-alpha, Hedgehog, Wnt, and others that influence cell differentiation and proliferation decisions. Under normal physiological growth conditions, the cilium forms after mitosis and in quiescent cells, extending from a basal body centered at a centriole, with timed resorption in G0 or early G1. Cancer cells have altered ciliary dynamics, with some (medulloblastomas and basal cell carcinomas) often dependent on cilia, and other tumor types downregulating them. In prior work, we defıned Aurora-A, an oncogenic kinase typically thought of as a mitotic regulator, as transiently activated at the basal body, and absolutely required for resorption of cilia at the G0/G1 boundary, and we showed the targeted Aurora-A inhibitor entirely blocked ciliary resorption. In subsequent work, we found that a second drug, the EGFR inhibitor erlotinib, al	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=160420&p_lang=2	ru_RU
dc.language.iso	ru	ru_RU
dc.publisher	AACR	ru_RU
dc.subject	primary cilium	ru_RU
dc.subject	ALisertib	ru_RU
dc.subject	Sunitinib	ru_RU
dc.title	Unexpected activity of multiple targeted cancer drugs in regulating ciliary dynamics	ru_RU
dc.type	Conference proceedings in international journals and collections	ru_RU