KFU. Card publication. Interplay Between Hydrogen Sulfide and Adrenergic and Muscarinic Receptors in the Mouse Atrium

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FEDERAL UNIVERSITY

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INTERPLAY BETWEEN HYDROGEN SULFIDE AND ADRENERGIC AND MUSCARINIC RECEPTORS IN THE MOUSE ATRIUM

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Lifanova Anastasiya Sergeevna, author

Sitdikova Guzel Faritovna, author

Khaertdinov Nail Nazimovich, author

Bibliographic description in the original language

Lifanova A, Khaertdinov N, Sitdikova G., Interplay Between Hydrogen Sulfide and Adrenergic and Muscarinic Receptors in the Mouse Atrium//BioNanoScience. - 2017. - Vol.7, Is.2. - P.306-308.

Annotation

Hydrogen sulfide (H2S) is synthesized endogenously, and it has a negative inotropic effect on myocardium of different animal species. Interaction between H2S and adrenergic and muscarinic receptors in regulation of mouse atrium contractile function was investigated in this study. Sodium hydrosulfide (NaHS, 300 μM), the H2S donor, decreased the contraction force of atrium. The effect of the H2S donor under β-AR stimulation showed no differences comparison to control values. The agonist of muscarinic receptors carbachol (1 μM) induced a negative inotropic effect and partially prevented the reduction of cardiac muscle contractility by NaHS. Moreover, the effect of carbachol was more pronounced after preliminary application of NaHS. At the same time, after inhibition of β-AR (propranolol, 1 μM) or muscarinic receptors (atropine, 1 μM), negative inotropic effect of NaHS was the same as in control conditions.

Keywords

Hydrogen sulfide (H2S), mouse atrium, muscarinic receptors, β-adrenoceptors

The name of the journal

BioNanoScience

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019117734&doi=10.1007%2fs12668-016-0355-1&partnerID=40&md5=2eef48772064895c9895295665193c1a

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=158087&p_lang=2

Resource files

File name	Size (MB)	Format
lifanova2016.pdf	0,44	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Lifanova Anastasiya Sergeevna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Khaertdinov Nail Nazimovich	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Lifanova A, Khaertdinov N, Sitdikova G., Interplay Between Hydrogen Sulfide and Adrenergic and Muscarinic Receptors in the Mouse Atrium//BioNanoScience. - 2017. - Vol.7, Is.2. - P.306-308.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=158087&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	Hydrogen sulfide (H2S) is synthesized endogenously, and it has a negative inotropic effect on myocardium of different animal species. Interaction between H2S and adrenergic and muscarinic receptors in regulation of mouse atrium contractile function was investigated in this study. Sodium hydrosulfide (NaHS, 300 μM), the H2S donor, decreased the contraction force of atrium. The effect of the H2S donor under β-AR stimulation showed no differences comparison to control values. The agonist of muscarinic receptors carbachol (1 μM) induced a negative inotropic effect and partially prevented the reduction of cardiac muscle contractility by NaHS. Moreover, the effect of carbachol was more pronounced after preliminary application of NaHS. At the same time, after inhibition of β-AR (propranolol, 1 μM) or muscarinic receptors (atropine, 1 μM), negative inotropic effect of NaHS was the same as in control conditions.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hydrogen sulfide (H2S)	ru_RU
dc.subject	mouse atrium	ru_RU
dc.subject	muscarinic receptors	ru_RU
dc.subject	β-adrenoceptors	ru_RU
dc.title	Interplay Between Hydrogen Sulfide and Adrenergic and Muscarinic Receptors in the Mouse Atrium	ru_RU
dc.type	Articles in international journals and collections	ru_RU