KFU. Card publication. Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring

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EFFECTS OF MATERNAL HYPERHOMOCYSTEINEMIA ON THE EARLY PHYSICAL DEVELOPMENT AND NEUROBEHAVIORAL MATURATION OF RAT OFFSPRING

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Gerasimova Elena Vyacheslavovna, author

Zakirova Gulshat Foatovna, author

Sitdikova Guzel Faritovna, author

Bibliographic description in the original language

Gerasimova E. Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring / E. Gerasimova, O. Yakovleva, G. Burkhanova, G. Ziyatdinova, N. Khaertdinov, G. Sitdikova // BioNanoScience. - 2017. - V. 7. - � 1. - P. 155-158.

Annotation

During pregnancy, several complications have been associated with hyperhomocysteinemia and elevated homocysteine (Hcy) levels have been shown to play a role in the etiology of preeclampsia, placental abruption, intrauterine growth retardation, and neural tube defects. In the present work we aimed to investigate the effects of maternal Hcy on the development and neurobehavioral maturation of the offspring. On the pups, we performed a follow-up of classical parameters of development such as body weight, eyelid opening, ear unfolding, incisor eruption and the appearance of hair, and subjected the pups to various tests representative of neurobehavioral maturation extending from 4th to 20th postnatal days (righting reflex, negative geotaxis, cliff avoidance, head shake, acoustic startle reflex, free-fall righting, cliff avoidance caused by visual stimulus, olfactory discrimination). We have shown that newborn animals were characterized by lower body weight and higher mortality.

Keywords

Keywords: maternal hyperhomocysteinemia, neonatal development, rat, neurobehavioral maturation

The name of the journal

BioNanoScience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=156451&p_lang=2

Resource files

File name	Size (MB)	Format
10.1007_s12668_016_0326_6.pdf	0,52	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gerasimova Elena Vyacheslavovna	ru_RU
dc.contributor.author	Zakirova Gulshat Foatovna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Gerasimova �. Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring / E. Gerasimova, O. Yakovleva, G. Burkhanova, G. Ziyatdinova, N. Khaertdinov, G. Sitdikova // BioNanoScience. - 2017. - V. 7. - � 1. - P. 155-158.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=156451&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	During pregnancy, several complications have been associated with hyperhomocysteinemia and elevated homocysteine (Hcy) levels have been shown to play a role in the etiology of preeclampsia, placental abruption, intrauterine growth retardation, and neural tube defects. In the present work we aimed to investigate the effects of maternal Hcy on the development and neurobehavioral maturation of the offspring. On the pups, we performed a follow-up of classical parameters of development such as body weight, eyelid opening, ear unfolding, incisor eruption and the appearance of hair, and subjected the pups to various tests representative of neurobehavioral maturation extending from 4th to 20th postnatal days (righting reflex, negative geotaxis, cliff avoidance, head shake, acoustic startle reflex, free-fall righting, cliff avoidance caused by visual stimulus, olfactory discrimination). We have shown that newborn animals were characterized by lower body weight and higher mortality.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Keywords: maternal hyperhomocysteinemia	ru_RU
dc.subject	neonatal development	ru_RU
dc.subject	rat	ru_RU
dc.subject	neurobehavioral maturation	ru_RU
dc.title	Effects of Maternal Hyperhomocysteinemia on the Early Physical Development and Neurobehavioral Maturation of Rat Offspring	ru_RU
dc.type	Articles in international journals and collections	ru_RU