Kazan (Volga region) Federal University, KFU
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Form of presentationArticles in international journals and collections
Year of publication2017
  • Ziganshina Liliya Evgenevna, author
  • Kong Khong Khan , author
  • Khaziakhmetova Veronika Nikolaevna, author
  • Bibliographic description in the original language Khaziakhmetova V.The Effects of Haloperidol on Acute Carrageenan-Induced Inflammation/Khaziakhmetova, V., Baiysbekov K., Torobekov Sh., Hanh Cong, Ziganshina L. // NanoBioScience. - 2017 – pp 442–445 DOI: 10.1007/s12668-017-0392-4.
    Annotation The objective of the study was to assess potential anti-inflammatory or pro-inflammatory effects of haloperidol, a classic typical neuroleptic, a butyrophenone derivative. It has been hypothesized that the anti-inflammatory mechanisms of some psychotropic drugs might become a rationale for their use for potential prevention of neurodegenirative diseases, including Alzheimer's, which are known to include chronic inflammation as disease progression component. We looked at the effects of haloperidol on the acute carrageenan-induced inflammation of rat paws and showed that haloperidol with prolonged use (for 7 days prior to edema modeling) considerably increased the inflammatory response at 48 h. A single dose of haloperidol also stimulated the progression of inflammation but at earlier time points—at 3 and 4 h after carrageenan injection.
    Keywords Acute inflammation, Carrageenan, Haloperidol,Rats
    The name of the journal Springerlink
    URL http://link.springer.com/article/10.1007/s12668-017-0392-4
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=154411&p_lang=2

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