KFU. Card publication. Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo

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INHIBITION OF CORTICAL ACTIVITY AND APOPTOSIS CAUSED BY ETHANOL IN NEONATAL RATS IN VIVO

Form of presentation

Articles in international journals and collections

Year of publication

2017

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Authors, employees of KFU

Sitdikova Guzel Faritovna, author

Bibliographic description in the original language

Julia Lebedeva1,2,3,?, Andrei Zakharov1,4,?, Elena Ogievetsky2,3, Alina Minlebaeva2,3, Rustem Kurbanov1, Elena Gerasimova1, Guzel Sitdikova1,? and Roustem Khazipov1 Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo // Cerebral Cortex, February 2017;27: 1068–1082

Annotation

Alcohol consumption during pregnancy causes fetal alcohol spectrum disorder, which includes neuroapoptosis and neurobehavioral deficits. The neuroapoptotic effects of alcohol have been hypothesized to involve suppression of brain activity. However, in vitro studies suggest that ethanol acts as a potent stimulant of cortical activity.We explored the effects of alcohol (1–6 g/kg) on electrical activity in the rat somatosensory cortex in vivo at postnatal days P1–23 and compared them with its apoptotic actions. At P4–7, when the peak of alcohol-induced apoptosiswas observed, alcohol strongly suppressed spontaneous gamma and spindle-bursts and almost completely silenced neurons in a dose-dependent manner. The dose-dependence of suppression of neuronal activity strongly correlated with the alcohol-induced neuroapoptosis. Alcohol also profoundly inhibited sensory-evoked bursts and suppressed motor activity, a physiological trigger of cortical activity bursts in newborns. The suppressive effe

Keywords

apoptosis, electroencephalogram, ethanol, fetal alcohol syndrome, neonate, neuronal network, rat, sensory-evoked potentials

The name of the journal

Cerebral Cortex

URL

https://academic.oup.com/cercor/article/27/2/1068/3056288/Inhibition-of-Cortical-Activity-and-Apoptosis

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=154353&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Julia Lebedeva1,2,3,?, Andrei Zakharov1,4,?, Elena Ogievetsky2,3, Alina Minlebaeva2,3, Rustem Kurbanov1, Elena Gerasimova1, Guzel Sitdikova1,? and Roustem Khazipov1 Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo // Cerebral Cortex, February 2017;27: 1068–1082	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=154353&p_lang=2	ru_RU
dc.description.abstract	Cerebral Cortex	ru_RU
dc.description.abstract	Alcohol consumption during pregnancy causes fetal alcohol spectrum disorder, which includes neuroapoptosis and neurobehavioral deficits. The neuroapoptotic effects of alcohol have been hypothesized to involve suppression of brain activity. However, in vitro studies suggest that ethanol acts as a potent stimulant of cortical activity.We explored the effects of alcohol (1–6 g/kg) on electrical activity in the rat somatosensory cortex in vivo at postnatal days P1–23 and compared them with its apoptotic actions. At P4–7, when the peak of alcohol-induced apoptosiswas observed, alcohol strongly suppressed spontaneous gamma and spindle-bursts and almost completely silenced neurons in a dose-dependent manner. The dose-dependence of suppression of neuronal activity strongly correlated with the alcohol-induced neuroapoptosis. Alcohol also profoundly inhibited sensory-evoked bursts and suppressed motor activity, a physiological trigger of cortical activity bursts in newborns. The suppressive effe	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	apoptosis	ru_RU
dc.subject	electroencephalogram	ru_RU
dc.subject	ethanol	ru_RU
dc.subject	fetal alcohol syndrome	ru_RU
dc.subject	neonate	ru_RU
dc.subject	neuronal network	ru_RU
dc.subject	rat	ru_RU
dc.subject	sensory-evoked potentials	ru_RU
dc.title	Inhibition of Cortical Activity and Apoptosis Caused by Ethanol in Neonatal Rats In Vivo	ru_RU
dc.type	Articles in international journals and collections	ru_RU