KFU. Card publication. NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

NPY1 RECEPTORS PARTICIPATE IN THE REGULATION OF MYOCARDIAL CONTRACTILITY IN RATS

Form of presentation

Articles in international journals and collections

Year of publication

2017

��

��

Authors, employees of KFU

Anikina Tatyana Andreevna, author

Zverev Aleksey Anatolevich, author

Zefirov Timur Lvovich, author

Krylova Alevtina Vasilevna, author

Other authors

Masliukov Petor Mikhailovich, author

Bibliographic description in the original language

Masliukov, P.M. NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats / P.M. Masliukov, T.A. Anikina, A.A Zverev, A.V. Krylova, K.Y. Moiseev, T.L. Zefirov // Bulletin of Experimental Biology and Medicine, - 2017, � 2, - P.418-420

Annotation

Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10—7 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY1 receptors in myocardial contraction

Keywords

neuropeptide Ytypes of NPY receptorsmyocardial contractilityrat

The name of the journal

Bulletin of Experimental Biology and Medicine

URL

http://link.springer.com/article/10.1007%2Fs10517-017-3629-x

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=153471&p_lang=2

Resource files

File name	Size (MB)	Format
bjulleten_2017.pdf	1,56	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Anikina Tatyana Andreevna	ru_RU
dc.contributor.author	Zverev Aleksey Anatolevich	ru_RU
dc.contributor.author	Zefirov Timur Lvovich	ru_RU
dc.contributor.author	Krylova Alevtina Vasilevna	ru_RU
dc.contributor.author	Masliukov Petor Mikhailovich	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	Masliukov, P.M. NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats / P.M. Masliukov, T.A. Anikina, A.A Zverev, A.V. Krylova, K.Y. Moiseev, T.L. Zefirov // Bulletin of Experimental Biology and Medicine, - 2017, � 2, - P.418-420	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=153471&p_lang=2	ru_RU
dc.description.abstract	Bulletin of Experimental Biology and Medicine	ru_RU
dc.description.abstract	Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10—7 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY1 receptors in myocardial contraction	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	NPY1 Receptors Participate in the Regulation of Myocardial Contractility in Rats	ru_RU
dc.type	Articles in international journals and collections	ru_RU