KFU. Card publication. Anti-inflammatory activity of novel (S)-naproxen derivatives

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

ANTI-INFLAMMATORY ACTIVITY OF NOVEL (S)-NAPROXEN DERIVATIVES

Form of presentation

Articles in international journals and collections

Year of publication

2017

Язык

английский

Authors, employees of KFU

Ziganshina Liliya Evgenevna, author

Kong Khong Khan , author

Kurbangalieva Almira Rafaelovna, author

Latypova Liliya Zinnurovna, author

Authors, postgraduates KFU

Kong Khong Khan, postgraduate kfu

Sibgatullina Regina Rifatovna, postgraduate kfu

Bibliographic description in the original language

H. Cong, R. Sibgatullina, L. Latypova, A. Kurbangalieva, L. Ziganshina. Anti-inflammatory activity of novel (S)-naproxen derivatives // BioNanoSci. - 2017. - V. 7. - № 1. - P. 189-193.

Annotation

In order to optimize the study of the antiinflammatory activity of novel drugs, in the current study, we used simple in vitro test system, which included osmotic and free radical hemolysis of human erythrocytes and human platelets aggregation, to screen for potential anti-inflammatory activity of three newly developed (S)-naproxen derivatives. We selected one of them (L3), which performed in in vitro tests nearly as well as naproxen, and studied their anti-inflammatory effects on in vivo model of inflammation, induced by carragenan. L3 was comparable to naproxen in its anti-inflammatory effects, suggesting that the studied simple inexpensive in vitro tests of erythrocyte osmotic and free radical hemolysis and human platelets aggregation could be used for pre-screening of potential anti-inflammatory agents.

Keywords

Hemolysis, platelet aggregation, carrageenan, anti-inflammatory drugs, naproxen, 2(5H)-furanone

The name of the journal

BioNanoScience

URL

https://link.springer.com/article/10.1007/s12668-016-0329-3

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=153362&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Liliya Evgenevna	ru_RU
dc.contributor.author	Kong Khong Khan	ru_RU
dc.contributor.author	Kurbangalieva Almira Rafaelovna	ru_RU
dc.contributor.author	Latypova Liliya Zinnurovna	ru_RU
dc.contributor.author	Kong Khong Khan	ru_RU
dc.contributor.author	Sibgatullina Regina Rifatovna	ru_RU
dc.date.accessioned	2017-01-01T00:00:00Z	ru_RU
dc.date.available	2017-01-01T00:00:00Z	ru_RU
dc.date.issued	2017	ru_RU
dc.identifier.citation	H. Cong, R. Sibgatullina, L. Latypova, A. Kurbangalieva, L. Ziganshina. Anti-inflammatory activity of novel (S)-naproxen derivatives // BioNanoSci. - 2017. - V. 7. - № 1. - P. 189-193.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=153362&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.description.abstract	In order to optimize the study of the antiinflammatory activity of novel drugs, in the current study, we used simple in vitro test system, which included osmotic and free radical hemolysis of human erythrocytes and human platelets aggregation, to screen for potential anti-inflammatory activity of three newly developed (S)-naproxen derivatives. We selected one of them (L3), which performed in in vitro tests nearly as well as naproxen, and studied their anti-inflammatory effects on in vivo model of inflammation, induced by carragenan. L3 was comparable to naproxen in its anti-inflammatory effects, suggesting that the studied simple inexpensive in vitro tests of erythrocyte osmotic and free radical hemolysis and human platelets aggregation could be used for pre-screening of potential anti-inflammatory agents.	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Hemolysis	ru_RU
dc.subject	platelet aggregation	ru_RU
dc.subject	carrageenan	ru_RU
dc.subject	anti-inflammatory drugs	ru_RU
dc.subject	naproxen	ru_RU
dc.subject	2(5H)-furanone	ru_RU
dc.title	Anti-inflammatory activity of novel (S)-naproxen derivatives	ru_RU
dc.type	Articles in international journals and collections	ru_RU