KFU. Card publication. Homocysteine augments BK channel activity and decreases exocytosis of secretory granules in rat GH3 cells

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FEDERAL UNIVERSITY

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HOMOCYSTEINE AUGMENTS BK CHANNEL ACTIVITY AND DECREASES EXOCYTOSIS OF SECRETORY GRANULES IN RAT GH3 CELLS

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Gayfullina Aysylu Shagitovna, author

Sadykova Alsu Nailovna, author

Sitdikova Guzel Faritovna, author

Yakovlev Aleksey Valerevich, author

Other authors

Hermann Anton , author

Weiger Thomas , author

Bibliographic description in the original language

Gaifullina A. Homocysteine augments BK channel activity and decreases exocytosis of secretory granules in rat GH3 cells /Yakovlev A., Mustafina A., Weiger T., Hermann A., Sitdikova G.// FEBS Lett.- 2016 Oct;590(19):3375-3384. doi: 10.1002/1873-3468.12381

Annotation

FEBS Letters

Keywords

BK channels; exocytosis; homocysteine; oxidative stress

The name of the journal

FEBS LETT

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=153017&p_lang=2

Resource files

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Gaifullina_A._Homocysteine_augments_BK_channel_activity_and.jpg	0,14	jpg	show / download
Gaifullina_A._Homocysteine_augments_BK_channel_activity_and.pdf	0,11	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Gayfullina Aysylu Shagitovna	ru_RU
dc.contributor.author	Sadykova Alsu Nailovna	ru_RU
dc.contributor.author	Sitdikova Guzel Faritovna	ru_RU
dc.contributor.author	Yakovlev Aleksey Valerevich	ru_RU
dc.contributor.author	Hermann Anton	ru_RU
dc.contributor.author	Weiger Thomas	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Gaifullina A. Homocysteine augments BK channel activity and decreases exocytosis of secretory granules in rat GH3 cells /Yakovlev A., Mustafina A., Weiger T., Hermann A., Sitdikova G.// FEBS Lett.- 2016 Oct;590(19):3375-3384. doi: 10.1002/1873-3468.12381	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=153017&p_lang=2	ru_RU
dc.description.abstract	FEBS LETT	ru_RU
dc.description.abstract	FEBS Letters	ru_RU
dc.description.abstract	In this study, we investigated the effects of L-homocysteine (Hcy) on maxi calcium-activated potassium (BK) channels and on exocytosis of secretory granules in GH3 rat pituitary-derived cells. A major finding of our study indicates that short-term application of Hcy increased the open probability of oxidized BK channels in inside-out recordings. Whole-cell recordings show that extracellular Hcy also augmented BK currents during long-term application. Furthermore, Hcy decreased the exocytosis of secretory granules. This decrease was partially prevented by the BK channel inhibitor paxilline and fully prevented by N-acetylcysteine, a reactive oxygen species scavenger. Taken together, our data show that elevation of cellular Hcy level induces oxidative stress, increases BK channel activity, and decreases exocytosis of secretory granules. These findings may provide insight into some of the developmental impairments and neurotoxicity associated with Hyperhomocysteinemia (HHcy)	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Homocysteine augments BK channel activity and decreases exocytosis of secretory granules in rat GH3 cells	ru_RU
dc.type	Articles in international journals and collections	ru_RU