KFU. Card publication. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure

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FEDERAL UNIVERSITY

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THE STUDY OF THE DEPENDENCE OF PHLOGOTROPIC AND MEMBRANE-TROPIC ACTIVITY OF PHOSPHONATES ON THEIR CHEMICAL STRUCTURE

Form of presentation

Articles in Russian journals and collections

Year of publication

2016

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Authors, employees of KFU

Ziganshina Liliya Evgenevna, author

Khaziakhmetova Veronika Nikolaevna, author

Bibliographic description in the original language

Khaziakhmetova V. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure. /Khaziakhmetova V., Khaziakhmetov D. , Ziganshin A. , Ziganshina L.// Research Journal of Pharmaceutical, Biological and Chemical Sciences - 2016.- 7(6)-pp.2931-2937.

Annotation

This paper deals with the study of the anti-inflammatory and membranotropic activity of dimephosphone, mephoprane and new chemical synthesis products belonging to different series of substitut-ed phosphonic acid derivatives - monophosphonates. The effect of monophosphonates on the intensity of carrageenin inflammation in mice and rats was studied. The relationship of chemical structure and membrane-protective activity was analyzed on the models of osmotic and free-radical hemolysis. It was established that the organophosphorousc compounds - derivatives of alkylphosphonic acids - show anti-inflammatory and membrane-tropic activity. The anti-inflammatory and membrane-tropic activity of functionally substituted monophosphonates depends on the length of the hydrocarbon radicals in the ester fragments of the molecule: the greater length and the presence of the methyl radicals and a carbonyl (carboxyl) group in the alkyl frag-ment of the molecule provide greater activity. The greatest activi

Keywords

phosphonates, dimephosphone, ephorane, carrageenin, inflammation, free radical hemolysis, red blood cell osmotic hemolysis, membrane-tropic activity, rats, mice.

The name of the journal

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=149212&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Ziganshina Liliya Evgenevna	ru_RU
dc.contributor.author	Khaziakhmetova Veronika Nikolaevna	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Khaziakhmetova V. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure. /Khaziakhmetova V., Khaziakhmetov D. , Ziganshin A. , Ziganshina L.// Research Journal of Pharmaceutical, Biological and Chemical Sciences - 2016.- 7(6)-pp.2931-2937.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=149212&p_lang=2	ru_RU
dc.description.abstract	Research Journal of Pharmaceutical, Biological and Chemical Sciences	ru_RU
dc.description.abstract	This paper deals with the study of the anti-inflammatory and membranotropic activity of dimephosphone, mephoprane and new chemical synthesis products belonging to different series of substitut-ed phosphonic acid derivatives - monophosphonates. The effect of monophosphonates on the intensity of carrageenin inflammation in mice and rats was studied. The relationship of chemical structure and membrane-protective activity was analyzed on the models of osmotic and free-radical hemolysis. It was established that the organophosphorousc compounds - derivatives of alkylphosphonic acids - show anti-inflammatory and membrane-tropic activity. The anti-inflammatory and membrane-tropic activity of functionally substituted monophosphonates depends on the length of the hydrocarbon radicals in the ester fragments of the molecule: the greater length and the presence of the methyl radicals and a carbonyl (carboxyl) group in the alkyl frag-ment of the molecule provide greater activity. The greatest activi	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	phosphonates	ru_RU
dc.subject	dimephosphone	ru_RU
dc.subject	ephorane	ru_RU
dc.subject	carrageenin	ru_RU
dc.subject	inflammation	ru_RU
dc.subject	free radical hemolysis	ru_RU
dc.subject	red blood cell osmotic hemolysis	ru_RU
dc.subject	membrane-tropic activity	ru_RU
dc.subject	rats	ru_RU
dc.subject	mice.	ru_RU
dc.title	The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure	ru_RU
dc.type	Articles in Russian journals and collections	ru_RU