Kazan (Volga region) Federal University, KFU
KAZAN
FEDERAL UNIVERSITY
 
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THE STUDY OF THE DEPENDENCE OF PHLOGOTROPIC AND MEMBRANE-TROPIC ACTIVITY OF PHOSPHONATES ON THEIR CHEMICAL STRUCTURE
Form of presentationArticles in Russian journals and collections
Year of publication2016
Языканглийский
  • Ziganshina Liliya Evgenevna, author
  • Khaziakhmetova Veronika Nikolaevna, author
  • Bibliographic description in the original language Khaziakhmetova V. The Study of The Dependence of Phlogotropic And Membrane-Tropic Activity of Phosphonates on Their Chemical Structure. /Khaziakhmetova V., Khaziakhmetov D. , Ziganshin A. , Ziganshina L.// Research Journal of Pharmaceutical, Biological and Chemical Sciences - 2016.- 7(6)-pp.2931-2937.
    Annotation This paper deals with the study of the anti-inflammatory and membranotropic activity of dimephosphone, mephoprane and new chemical synthesis products belonging to different series of substitut-ed phosphonic acid derivatives - monophosphonates. The effect of monophosphonates on the intensity of carrageenin inflammation in mice and rats was studied. The relationship of chemical structure and membrane-protective activity was analyzed on the models of osmotic and free-radical hemolysis. It was established that the organophosphorousc compounds - derivatives of alkylphosphonic acids - show anti-inflammatory and membrane-tropic activity. The anti-inflammatory and membrane-tropic activity of functionally substituted monophosphonates depends on the length of the hydrocarbon radicals in the ester fragments of the molecule: the greater length and the presence of the methyl radicals and a carbonyl (carboxyl) group in the alkyl frag-ment of the molecule provide greater activity. The greatest activi
    Keywords phosphonates, dimephosphone, ephorane, carrageenin, inflammation, free radical hemolysis, red blood cell osmotic hemolysis, membrane-tropic activity, rats, mice.
    The name of the journal Research Journal of Pharmaceutical, Biological and Chemical Sciences
    Please use this ID to quote from or refer to the card https://repository.kpfu.ru/eng/?p_id=149212&p_lang=2

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