KFU. Card publication. NMR Studies of the Mn2+ Interactions with Amyloid Peptide Aβ13-23 in Water Environment

KAZAN
FEDERAL UNIVERSITY

- RUS
- 中文
- ES

NMR STUDIES OF THE MN2+ INTERACTIONS WITH AMYLOID PEPTIDE Aβ13-23 IN WATER ENVIRONMENT

Form of presentation

Articles in international journals and collections

Year of publication

2016

Authors, employees of KFU

Karataeva Farida Khaydarovna, author

Klochkov Vladimir Vasilevich, author

Usachev Konstantin Sergeevich, author

Authors, postgraduates KFU

Abdrakhmanov Rustam Zhamilevich, postgraduate kfu

Bibliographic description in the original language

Binding of Mn2+ ions to the fragment of beta-amyloid peptide (Aβ13-23) was studied. Manganese complexation induces important structural changes within the C-terminal segment of the peptide. Investigation of peptide Ab metal ion binding was made by MnCl2 salt titration and recording 2D 1H-1H NMR TOCSY spectra (TOtal Correlation SpectroscopY). Multidimensional NMR techniques were performed to understand the details of the conformational behavior of the peptide and to reveal the metalbinding sites. According to changes in NMR spectra, the manganese-binding center of the Aβ13-23 peptide is associated with the aspartate residue.

Keywords

Amyloid peptide Aβ13-23, NMR spectroscopy, Mn2+ ions

The name of the journal

BioNanoScience

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=148699&p_lang=2

Full metadata record

Field DC	Value	Language
dc.contributor.author	Karataeva Farida Khaydarovna	ru_RU
dc.contributor.author	Klochkov Vladimir Vasilevich	ru_RU
dc.contributor.author	Usachev Konstantin Sergeevich	ru_RU
dc.contributor.author	Abdrakhmanov Rustam Zhamilevich	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Binding of Mn2+ ions to the fragment of beta-amyloid peptide (Aβ13-23) was studied. Manganese complexation induces important structural changes within the C-terminal segment of the peptide. Investigation of peptide Ab metal ion binding was made by MnCl2 salt titration and recording 2D 1H-1H NMR TOCSY spectra (TOtal Correlation SpectroscopY). Multidimensional NMR techniques were performed to understand the details of the conformational behavior of the peptide and to reveal the metalbinding sites. According to changes in NMR spectra, the manganese-binding center of the Aβ13-23 peptide is associated with the aspartate residue.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=148699&p_lang=2	ru_RU
dc.description.abstract	BioNanoScience	ru_RU
dc.language.iso	ru	ru_RU
dc.subject	Amyloid peptide Aβ13-23	ru_RU
dc.subject	NMR spectroscopy	ru_RU
dc.subject	Mn2+ ions	ru_RU
dc.title	NMR Studies of the Mn2+ Interactions with Amyloid Peptide Aβ13-23 in Water Environment	ru_RU
dc.type	Articles in international journals and collections	ru_RU