KFU. Card publication. Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy

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FEDERAL UNIVERSITY

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AMMONIA-INDUCED SENESCENCE IN CULTURED RAT ASTROCYTES AND IN HUMAN CEREBRAL CORTEX IN HEPATIC ENCEPHALOPATHY

Form of presentation

Articles in international journals and collections

Year of publication

2016

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Authors, employees of KFU

Shafigullina Aygul Kasyymovna, author

Other authors

Bidmon Hans J. , author

Görg Boris , author

Häussinger Dieter , author

Karababa Ayse , author

Bibliographic description in the original language

Görg, B. Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy / B. Görg, A. Karababa, A. Shafigullina, H.J. Bidmon, D. Häussinger // Glia. – 2015. – Vol. 63. - � 1. – P. 37-50.

Annotation

Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is due to a low-grade cerebral edema associated with oxidative/nitrosative stress. Recent reports suggest that cognitive impairment in cirrhotic patients may not resolve completely after an attack of manifest HE. As astrocyte dysfunction is central to the pathogenesis of HE and astrocytes are critically involved in synaptic plasticity, we tested for sustained impairment of astrocyte function by analyzing expression levels of senescence biomarkers in ammonia-treated cultured rat astrocytes and in postmortem brain samples from cirrhotic patients with or without HE. NH4 Cl time- and dose-dependently inhibited proliferation of cultured astrocytes by up to 45% (5 mmol/L, 72 h) and strongly increased senescence-associated β-galactosidase activity. Inhibition of astrocyte proliferation by ammonia was mediated by a l-methionine sulfoximine-, oxidative stress-, and p38(MAPK) -dependent activation of p53 associated wit

Keywords

ammonia; astrocytes; glutamine; senescence

The name of the journal

Glia

On-line resource for training course

http://dspace.kpfu.ru/xmlui/bitstream/handle/net/108583/Ammonia_induced_senescence__Goerg__2015.pdf?sequence=1&isAllowed=y

URL

https://www.ncbi.nlm.nih.gov/pubmed/25092802

Please use this ID to quote from or refer to the card

https://repository.kpfu.ru/eng/?p_id=148264&p_lang=2

Resource files

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Ammonia_induced_senescence__Goerg__2015.pdf	0,08	pdf	show / download

Full metadata record

Field DC	Value	Language
dc.contributor.author	Shafigullina Aygul Kasyymovna	ru_RU
dc.contributor.author	Bidmon Hans J.	ru_RU
dc.contributor.author	Görg Boris	ru_RU
dc.contributor.author	Görg Boris	ru_RU
dc.contributor.author	Häussinger Dieter	ru_RU
dc.contributor.author	Karababa Ayse	ru_RU
dc.date.accessioned	2016-01-01T00:00:00Z	ru_RU
dc.date.available	2016-01-01T00:00:00Z	ru_RU
dc.date.issued	2016	ru_RU
dc.identifier.citation	Görg, B. Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy / B. Görg, A. Karababa, A. Shafigullina, H.J. Bidmon, D. Häussinger // Glia. – 2015. – Vol. 63. - � 1. – P. 37-50.	ru_RU
dc.identifier.uri	https://repository.kpfu.ru/eng/?p_id=148264&p_lang=2	ru_RU
dc.description.abstract	Glia	ru_RU
dc.description.abstract	Hepatic encephalopathy (HE) is a frequent complication of liver cirrhosis and is due to a low-grade cerebral edema associated with oxidative/nitrosative stress. Recent reports suggest that cognitive impairment in cirrhotic patients may not resolve completely after an attack of manifest HE. As astrocyte dysfunction is central to the pathogenesis of HE and astrocytes are critically involved in synaptic plasticity, we tested for sustained impairment of astrocyte function by analyzing expression levels of senescence biomarkers in ammonia-treated cultured rat astrocytes and in postmortem brain samples from cirrhotic patients with or without HE. NH4 Cl time- and dose-dependently inhibited proliferation of cultured astrocytes by up to 45% (5 mmol/L, 72 h) and strongly increased senescence-associated β-galactosidase activity. Inhibition of astrocyte proliferation by ammonia was mediated by a l-methionine sulfoximine-, oxidative stress-, and p38(MAPK) -dependent activation of p53 associated wit	ru_RU
dc.language.iso	ru	ru_RU
dc.subject		ru_RU
dc.title	Ammonia-induced senescence in cultured rat astrocytes and in human cerebral cortex in hepatic encephalopathy	ru_RU
dc.type	Articles in international journals and collections	ru_RU